Sensor arrangement and method for operating a sensor arrangement
4 Assignments
0 Petitions
Accused Products
Abstract
Sensor arrangement, set up as an integrated circuit, having a substrate, at least three sensor electrodes arranged on the substrate such that, in an operating state in which an electrically conductive substance is introduced into the sensor arrangement, the sensor electrodes are coupled to one another by means of the electrically conductive substance, capture molecules immobilized on at least a portion of the sensor electrodes, wherein molecules to be detected can hybridize with the capture molecules, a control circuit for applying a first electrical signal to a selected sensor electrode and simultaneously applying a second electrical signal to at least two of the other sensor electrodes, the first electrical signal being a first temporally variable electrical signal and/or the second electrical signal being a second temporally variable electrical signal, a detection device, which is set up such that, in a first operating state, in which a reference liquid is introduced into the sensor arrangement, a reference value of a third temporally variable electrical signal resulting from the first temporally variable electrical signal and/or from the second temporally variable electrical signal is detected at the selected sensor electrode, and in a second operating state, in which an analyte possibly having molecules to be detected is introduced into the sensor arrangement, a sensor value of the third temporally variable electrical signal resulting from the first temporally variable electrical signal and/or from the second temporally variable electrical signal is detected at the selected sensor electrode, and an evaluation circuit, which, on the basis of the reference value and the sensor value, determines whether a hybridization event has taken place at the selected sensor electrode.
-
Citations
60 Claims
-
1-28. -28. (canceled)
-
29. A sensor arrangement, set up as an integrated circuit, comprising:
-
a substrate;
at least three sensor electrodes arranged on the substrate such that, in an operating state in which an electrically conductive substance is introduced into the sensor arrangement, the sensor electrodes are coupled to one another by means of the electrically conductive substance;
capture molecules immobilized on at least a portion of the sensor electrodes, wherein molecules to be detected can hybridize with the capture molecules;
a control circuit for applying a first electrical signal to a selected sensor electrode and simultaneously applying a second electrical signal to at least two of the other sensor electrodes, the first electrical signal being a first temporally variable electrical signal and/or the second electrical signal being a second temporally variable electrical signal;
a detection device, which is set up such that, in a first operating state, in which a reference liquid is introduced into the sensor arrangement, a reference value of a third temporally variable electrical signal resulting from the first temporally variable electrical signal and/or from the second temporally variable electrical signal is detected at the selected sensor electrode; and
in a second operating state, in which an analyte possibly having molecules to be detected is introduced into the sensor arrangement, a sensor value of the third temporally variable electrical signal resulting from the first temporally variable electrical signal and/or from the second temporally variable electrical signal is detected at the selected sensor electrode; and
an evaluation circuit, which, on the basis of the reference value and the sensor value, determines whether a hybridization event has taken place at the selected sensor electrode. - View Dependent Claims (30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52)
-
-
53. A sensor arrangement, set up as an integrated circuit, comprising:
-
a substrate;
at least three sensor electrodes arranged on the substrate such that, in an operating state in which an electrically conductive substance is introduced into the sensor arrangement, the sensor electrodes are coupled to one another by means of the electrically conductive substance;
capture molecules immobilized on at least a portion of the sensor electrodes, wherein molecules to be detected can hybridize with the capture molecules;
at least one reference sensor electrode being free of capture molecules with which molecules to be detected can hybridize;
a control circuit for applying a first electrical signal to a selected sensor electrode and to the reference sensor electrode and simultaneously applying a second electrical signal to at least one of the other sensor electrodes, the first electrical signal being a first temporally variable electrical signal and/or the second electrical signal being a second temporally variable electrical signal;
a detection device, which, in an operating state in which an analyte possibly having molecules to be detected is introduced into the sensor arrangement, a reference value of a third temporally variable electrical signal resulting from the first temporally variable electrical signal and/or from the second temporally variable electrical signal is detected at the reference sensor electrode;
ora sensor value of a third temporally variable electrical signal resulting from the first temporally variable electrical signal and/or from the second temporally variable electrical signal is detected at the selected sensor electrode; and
an evaluation circuit, which, on the basis of the reference value and the sensor value, determines whether a hybridization event has taken place at the selected sensor electrode. - View Dependent Claims (54)
-
-
55. A method for operating a sensor arrangement, comprising the steps of:
-
providing a sensor arrangement, set up as an integrated circuit, having;
a substrate;
at least three sensor electrodes arranged on the substrate such that, in an operating state in which an electrically conductive substance is introduced into the sensor arrangement, the sensor electrodes are coupled to one another by means of the electrically conductive substance;
capture molecules immobilized on at least a portion of the sensor electrodes, wherein molecules to be detected can hybridize with the capture molecules;
a control circuit;
a detection device; and
an evaluation circuit;
the control circuit applying a first electrical signal to a selected sensor electrode and simultaneously applying a second electrical signal to at least two of the other sensor electrodes, the first electrical signal being a first temporally variable electrical signal and/or the second electrical signal being a second temporally variable electrical signal;
in a first operating state, in which a reference liquid is introduced into the sensor arrangement, the detector device detecting at the selected sensor electrode a reference value of a third temporally variable electrical signal resulting from the first temporally variable electrical signal and/or from the second temporally variable electrical signal;
in a second operating state, in which an analyte possibly having molecules to be detected is introduced into the sensor arrangement, the detector device detecting at the selected sensor electrode, a sensor value of a third temporally variable electrical signal resulting from the first temporally variable electrical signal and/or from the second temporally variable electrical signal; and
the evaluation circuit determining, on the basis of the reference value and the sensor value, whether a hybridization event has taken place at the selected sensor electrode. - View Dependent Claims (56)
-
-
57. A sensor arrangement, set up as an integrated circuit, comprising:
-
a substrate;
at least three sensor electrodes arranged on the substrate such that, in an operating state in which an electrically conductive substance is introduced into the sensor arrangement, the sensor electrodes are coupled to one another by means of the electrically conductive substance;
capture molecules immobilized on at least a portion of the sensor electrodes, wherein molecules to be detected can hybridize with the capture molecules;
a control means for applying a first electrical signal to a selected sensor electrode and simultaneously applying a second electrical signal to at least two of the other sensor electrodes, the first electrical signal being a first temporally variable electrical signal and/or the second electrical signal being a second temporally variable electrical signal;
a detection means, which is set up such that, in a first operating state, in which a reference liquid is introduced into the sensor arrangement, a reference value of a third temporally variable electrical signal resulting from the first temporally variable electrical signal and/or from the second temporally variable electrical signal is detected at the selected sensor electrode; and
in a second operating state, in which an analyte possibly having molecules to be detected is introduced into the sensor arrangement, a sensor value of the third temporally variable electrical signal resulting from the first temporally variable electrical signal and/or from the second temporally variable electrical signal is detected at the selected sensor electrode; and
an evaluation means, which, on the basis of the reference value and the sensor value, determines whether a hybridization event has taken place at the selected sensor electrode.
-
-
58. A sensor arrangement, set up as an integrated circuit, comprising:
-
a substrate;
at least three sensor electrodes arranged on the substrate such that, in an operating state in which an electrically conductive substance is introduced into the sensor arrangement, the sensor electrodes are coupled to one another by means of the electrically conductive substance;
capture molecules immobilized on at least a portion of the sensor electrodes, wherein molecules to be detected can hybridize with the capture molecules;
at least one reference sensor electrode being free of capture molecules with which molecules to be detected can hybridize;
a control means for applying a first electrical signal to a selected sensor electrode and to the reference sensor electrode and simultaneously applying a second electrical signal to at least one of the other sensor electrodes, the first electrical signal being a first temporally variable electrical signal and/or the second electrical signal being a second temporally variable electrical signal;
a detection means, which, in an operating state in which an analyte possibly having molecules to be detected is introduced into the sensor arrangement, a reference value of a third temporally variable electrical signal resulting from the first temporally variable electrical signal and/or from the second temporally variable electrical signal is detected at the reference sensor electrode;
ora sensor value of a third temporally variable electrical signal resulting from the first temporally variable electrical signal and/or from the second temporally variable electrical signal is detected at the selected sensor electrode; and
an evaluation means, which, on the basis of the reference value and the sensor value, determines whether a hybridization event has taken place at the selected sensor electrode.
-
-
59. A method for operating a sensor arrangement, which set up as an integrated circuit, and has a substrate, at least three sensor electrodes arranged on the substrate such that, in an operating state in which an electrically conductive substance is introduced into the sensor arrangement, the sensor electrodes are coupled to one another by means of the electrically conductive substance, capture molecules immobilized on at least a portion of the sensor electrodes, wherein molecules to be detected can hybridize with the capture molecules, a control circuit, a detection device, and an evaluation circuit, the method comprising the steps of:
-
the control circuit applying a first electrical signal to a selected sensor electrode and simultaneously applying a second electrical signal to at least two of the other sensor electrodes, the first electrical signal being a first temporally variable electrical signal and/or the second electrical signal being a second temporally variable electrical signal;
in a first operating state, in which a reference liquid is introduced into the sensor arrangement, the detector device detecting at the selected sensor electrode a reference value of a third temporally variable electrical signal resulting from the first temporally variable electrical signal and/or from the second temporally variable electrical signal;
in a second operating state, in which an analyte possibly having molecules to be detected is introduced into the sensor arrangement, the detector device detecting at the selected sensor electrode, a sensor value of a third temporally variable electrical signal resulting from the first temporally variable electrical signal and/or from the second temporally variable electrical signal; and
the evaluation circuit determining, on the basis of the reference value and the sensor value, whether a hybridization event has taken place at the selected sensor electrode.
-
-
60. A method for operating a sensor arrangement, which is set up as an integrated circuit, and has a substrate, at least three sensor electrodes arranged on the substrate such that, in an operating state in which an electrically conductive substance is introduced into the sensor arrangement, the sensor electrodes are coupled to one another by means of the electrically conductive substance, capture molecules immobilized on at least a portion of the sensor electrodes, wherein molecules to be detected can hybridize with the capture molecules, at least one reference sensor electrode being free of capture molecules with which molecules to be detected can hybridize, a control circuit, and a detection device, the method comprising the step of:
-
the detection device detecting at the reference sensor electrode a reference value of a third temporally variable electrical signal resulting from the first temporally variable electrical signal and/or from the second temporally variable electrical signal, or a third temporally variable electrical signal resulting from the first temporally variable electrical signal and/or from the second temporally variable electrical signal; and
the evaluation circuit determining, on the basis of the reference value and the sensor value, whether a hybridization event has taken place at the selected sensor electrode.
-
Specification