Methods and apparatus for controlling ion current in an ion transmission device

• US 20050194543A1
• Filed: 02/22/2005
• Published: 09/08/2005
• Est. Priority Date: 02/23/2004
• Status: Abandoned Application

• Current Assignee: Andreas Hieke
• Original Assignee: Ciphergen Biosystems Incorporated
• Inventors: Hieke, Andreas
• Application Number:
  US11/063,801
• Publication Number:
  US 20050194543A1
• Time in Patent Office: Days
• US Class Current: 250/400
• CPC Class Codes: H01J 49/04 Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
• CPC Class Codes: H01J 49/062 Ion guides linear ion traps performing mass selection H01J49/4225, mass filters H01J49/421

Abstract

The invention provides apparatus and methods for controlling ion current in an ion transmission device. An apparatus of the present invention comprises an ion source, an ion transmission device, and a controller. The ion source and the ion transmission device are in ion communication therebetween, and the controller is in signal communication with both the ion source and the ion transmission device. The ion current of the ion transmission device may be controlled by coordinating at least one of the operating parameter values of the ion source with at least one of the operating parameter values of the ion transmission device. Such coordination may result in, for example, improved ion current in the ion transmission device. Also embraced by the present invention are mass spectrometer embodiments that include or use the apparatus or methods of the present invention for controlling ion current.

Claims

1. A method for controlling the ion current of an ion transmission device, wherein an ion source is in ion communication with and provides ions to the ion transmission device, the method comprising:

coordinating a value for each of at least one operating parameter of the ion source with a value for each of at least one operating parameter of the ion transmission device.

2. The method of claim 1, wherein the step of coordinating comprises setting the value for each of the at least one ion source operating parameters, wherein each said value is predetermined for each of the at least one ion source operating parameter.

3. The method of claim 2, wherein the predetermined value for each of the at least one ion source operating parameter is such that the ion source, when set with each said predetermined value, provides an increased amount of ions of a given mass range to the ion transmission device compared with the amount of ions of the given mass range provided when the respective operating parameters are not coordinated.

4. The method of claim 2, wherein the predetermined value for each of the at least one ion source operating parameter is such that the ion source, when set with each said predetermined value, provides an increased amount of ions of all mass ranges to the ion transmission device compared with the amount of ions of all mass ranges provided when the respective operating parameters are not coordinated.

5. The method of claim 1, wherein the ion transmission device provides ions to a mass spectrometer, an ion mobility spectrometer, or a total ion current measuring device.

6. The method of claim 1, wherein the step of coordinating comprises:

setting a value for each of the at least one ion transmission device operating parameter, wherein the values set for each of the at least one ion transmission device operating parameter is predetermined for a given mass range of ions; and

setting a value for each of the at least one ion source operating parameter, wherein the values set for each of the at least one ion source operating parameter is predetermined for the given mass range of ions.

7. The method of claim 1, wherein the step of coordinating comprises:

setting a first set of values for the at least one ion transmission device operating parameter; and

setting a first set of values for the at least one ion source operating parameter,

wherein the first set of values for the at least one ion source operating parameter is predetermined based on the first set of values for the at least one ion transmission device operating parameters.

8. The method of claim 1, wherein the step of coordinating comprises:

determining a value for each of the at least one ion transmission device operating parameter; and

setting a value for each of the at least the ion source operating parameters,

wherein the value set for each of the at least one ion source operating parameter is based on the value determined for each of the at least one ion transmission device operating parameter, and

wherein the value for each of the at least one ion source operating parameter is predetermined.

9. The method of claim 1, wherein the step of coordinating comprises:

setting the value for each of the at least one ion transmission device operating parameter; and

setting the value for each of the at least one ion source operating parameter,

wherein at least one of the values set for the ion source operating parameters is calculated based on at least one of the values set for ion transmission guide operating parameters.

10. The method of claim 1, wherein the ion source and the ion transmission device are in signal communication with a controller, the step of coordinating comprising:

setting with the controller at least one of the values of the at least one ion source operating parameter,

wherein the values of the ion source operating parameters set by the controller are predetermined for a given ion mass range.

11. The method of claim 1, wherein the ion source and the ion transmission device are in signal communication with a controller, the step of coordinating comprising:

setting with the controller at least one of the values of the at least one ion source operating parameter,

wherein at least one the values of the ion source operating parameters set by the controller is calculated based on at least one of the values of the at least one ion transmission device operating parameter.

12. The method of claim 1, wherein the ion transmission device comprises a multipole radio-frequency ion guide, and the at least one ion transmission guide operating parameter includes the peak amplitude and/or the frequency of the radio-frequency alternating current potential of at least one of the multipole ion guide electrodes.

13. The method of claim 1, wherein the ion source comprises at least one electrode, and the at least one ion source operating parameter includes the potential applied to at least one of the electrodes of the ion source.

14. The method of claim 1, wherein the ion source comprises a laser desorption/ionization ion source, a chemical ionization ion source, an electron impact ionization ion source, a photoionization ion source, an electrospray ionization ion source, or a plasma desorption ion source.

15. The method of claim 1, wherein the ion source comprises a gas flow field superposed on an electric field of the ion source.

16. An apparatus comprising:

an ion source;

an ion transmission device in ion communication with the ion source; and

a controller configured to coordinate the value of at least one ion source operating parameter with the value of at least one ion transmission device operating parameter.

17. The apparatus of claim 16, wherein the controller comprises a digital computer and memory.

18. The apparatus of claim 16, wherein the controller is in signal communication with the ion source and the ion transmission device.

19. The apparatus of claim 16, wherein the controller, when coordinating the respective values of the ion source and ion transmission device operating parameters, is configured to:

determine at least one of the values of the at least one ion transmission device operating parameter; and

set at least one of the values of the at least one ion source operating parameter,

wherein the values set for the ion source operating parameters are predetermined and based on at least one of the values determined for the at least one ion transmission device operating parameter.

20. The apparatus of claim 16, wherein the controller comprises memory and the predetermined ion source operating parameter values are stored in the memory.

21. The apparatus of claim 19, wherein the controller, when setting the values of the at least one ion source operating parameter, is configured to:

calculate at least one of the values of the at least ion source operating parameter,

wherein said calculation is based on at least one of the values determined for the at least one ion transmission device operating parameter.

22. The apparatus of claim 16, wherein the controller, when coordinating the respective values of the ion source and ion transmission device operating parameters, is configured to:

set at least one of the values of the at least one ion transmission device operating parameter; and

set at least one of the values of the at least one ion source operating parameter,

wherein the values set for the at least one ion source operating parameter are predetermined for a given mass range of ions, such that ions of the given mass range are provided from the ion source to the ion transmission device.

23. The apparatus of claim 16, wherein the ion source comprises at least one electrode that affects the potential experienced by ions in the ion source.

24. The apparatus of claim 23, wherein the at least one ion source operating parameter includes the magnitude of a direct current potential of at least one of the ion source electrodes.

25. The apparatus of claim 16, wherein the ion transmission device comprises a multipole radio-frequency ion guide.

26. The apparatus of claim 25, wherein the at least one ion transmission device operating parameter includes the amplitude of a radio-frequency alternating current potential of at least one of the multipole radio-frequency ion guide electrodes.

27. The apparatus of claim 25 or claim 26, wherein the multipole radio-frequency ion guide comprises a quadrupole ion guide, a hexapole ion guide, or an octopole ion guide.

28. The apparatus of claim 16 further comprising a mass analyzer in ion communication with the ion transmission device.

30. The apparatus of claims 16, wherein the ion source comprises a laser desorption/ionization ion source, a chemical ionization ion source, an electron impact ionization ion source, a photoionization ion source, an electrospray ionization ion source, or a plasma desorption ion source.

31. The apparatus of claim 16, wherein the ion source includes a gas flow field superposed on the electric field of the ion source.

32. A tandem mass spectrometer comprising:

the apparatus of claim 16;

a first mass analyzer in ion communication with said apparatus;

and a second mass analyzer in ion communication with the first mass analyzer.

33. The tandem mass spectrometer of claim 32 further comprising an ion detector.

34. The tandem mass spectrometer of claim 33, wherein the first mass analyzer and the second mass analyzer each comprises a quadrupole mass filter, a reflectron, a time-of-flight mass analyzer, an electric sector time-of-flight mass analyzer, a triple quadrupole apparatus, a Fourier transform ion cyclotron resonance mass analyzer, or a magnetic sector mass analyzer.

35. The tandem mass spectrometer of claim 32, wherein the ion source comprises a laser desorption/ionization ion source, a chemical ionization ion source, an electron impact ionization ion source, a photoionization ion source, an electrospray ionization ion source, or a plasma desorption ion source.

36. The tandem apparatus of claim 32, wherein the ion source includes a gas flow field superposed on the electric field of the ion source.

29. The apparatus of clam 28, wherein the mass analyzer comprises a quadrupole mass filter, a reflectron, a time-of-flight mass analyzer, an electric sector time-of-flight mass analyzer, a triple quadrupole apparatus, a Fourier transform ion cyclotron resonance mass analyzer, or a magnetic sector mass analyzer.