Fluidic programmable array devices and methods

• US 20050196321A1
• Filed: 06/03/2004
• Published: 09/08/2005
• Est. Priority Date: 03/03/2004
• Status: Abandoned Application

• Current Assignee: Zhili Huang
• Original Assignee: Zhili Huang
• Inventors: Huang, Zhili
• Application Number:
  US10/858,812
• Publication Number:
  US 20050196321A1
• Time in Patent Office: Days
• US Class Current: 422/68.1
• CPC Class Codes: B01L 2300/0861 Configuration of multiple channels and/or chambers in a single devices
• CPC Class Codes: B01L 2300/0864 comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
• CPC Class Codes: B01L 2300/0867 Multiple inlets and one sample wells, e.g. mixing, dilution
• CPC Class Codes: B01L 2300/087 Multiple sequential chambers
• CPC Class Codes: B01L 2400/0406 capillary forces
• CPC Class Codes: B01L 2400/0481 squeezing of channels or chambers
• CPC Class Codes: B01L 2400/0655 pinch valves
• CPC Class Codes: B01L 3/502707 characterised by the manufacture of the container or its components by shaping or joining plastic parts B29C59/00, B29C65/00; by laminating B32B37/00; manufacture of microstructural devices in general B81C
• CPC Class Codes: B01L 3/502738 characterised by integrated valves microvalves F16K99/0001
• CPC Class Codes: B01L 7/52 with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples amplification or hybridisation processes per se C12Q1/68; controlling sequential reactions for synthesis B01J19/0046
• CPC Class Codes: F16K 2099/0084 Chemistry or biology, e.g. "lab-on-a-chip" technology
• CPC Class Codes: F16K 99/0026 Valves using channel deformation
• CPC Class Codes: F16K 99/0044 using thermo-electric means
• CPC Class Codes: F16K 99/0048 using piezoelectric means
• CPC Class Codes: F16K 99/0061 actuated by an expanding gas or liquid volume

Abstract

This invention relates to array devices and methods for their fabrication. More specifically, the array devices have automatic flow control, probe array configuration, and dynamic chemical or biochemical reaction for rapid chemical or bio-molecule detection.

Claims

1. A fluidic programmable array device, comprising:

an elastomeric body;

a substrate;

a recess;

a fluidic channel; and

two loading wells.

2. The device of the claim 1, wherein the recess is a cylinder with a dome.

3. The device of the claim 1, wherein a spot reservoir comprises the recess in the elastomeric body and a portion of the substrate at the recess.

4. The device of the claim 3, wherein the spot reservoir is connected with the fluidic channel.

5. The device of the claim 1, wherein the substrate is made of a material that is able to couple chemicals or molecules on it.

6. The device of the claim 1, wherein the surface of the substrate is coated a material that is able to couple chemicals or molecules on it.

7. The device of the claim 1, wherein the two loading wells are on both ends of the fluidic channel.

8. The device of the claim 1, further comprising more than the one recess to form more than one spot reservoirs with the substrate, and more than the one fluidic channel connecting the spot reservoirs, wherein the spot reservoirs and the fluidic channels form an array.

9. A structure in a device made of elastomeric material, comprising:

a recess;

a fluidic channel;

a deformable membrane formed by the elastomeric material between a gap of the fluidic channel and the recess; and

the fluidic channel, the deformable membrane, and an actuator further form a pinch microvalve.

10. The device of the claim 9, wherein the recess has an elongated shape with a cylindrical top.

11. The device of the claim 9, wherein the actuator is a linear motion actuator inserted into the recess and touched the top of the recess.

12. The device of the claim 9, wherein the actuator embedded in a cavity formed by the recess and a substrate is a piezoelectric motion component with a head touched the top of the recess.

13. The device of the claim 9, wherein the actuator embedded in a cavity formed by the recess and a substrate is a magnetostrictive component with a head touched the top of the recess.

14. The device of the claim 9, wherein the actuator embedded in a cavity formed by the recess and a substrate is a thermopneumatic motion actuator, inside the cavity a liquid is filled and a microheater is built.

15. The device of the claim 9, wherein the at least three pinch microvalves form a peristaltic pump along the fluidic channel.

16. A fluidic programmable array device, comprising:

an elastomeric body;

a spot reservoir;

a fluidic channel; and

two loading wells.

17. The device of the claim 16, wherein the spot reservoir comprises a cavity formed by a recess in the elastomeric body and a pillar inlaid in the recess.

18. The device of the claim 17, wherein the top surface of the pillar is able to couple chemicals or molecules on it.

19. The device of the claim 17, wherein a through channel is in the center of the pillar to form a fluidic connecter to deliver a solution from outside of the device into the spot reservoir.

20. The device of the claim 16, wherein the spot reservoir is connected with the fluidic channel having the loading wells on the both ends.

21. The device of the claim 16, wherein the spot reservoir comprises a cavity inside the elastomeric body.

22. The device of the claim 21, wherein a channel in the elastomeric body connects the cavity from outside of the device.

23. The device of the claim 16, wherein the spot reservoir comprises a cavity inside the elastomeric body with an embedded substrate.

24. The device of the claim 23, wherein a center hole on the substrate and a channel in the elastomeric body connect the cavity from outside of the device.

25. The device of the claim 23, wherein a surface of the substrate is capable of coupling chemicals or molecules on it.

26. The device of the claim 16, wherein an array of the spot reservoirs is formed by more than the one spot reservoir and the one fluidic channel in the elastomeric body.