Energy-activated targeted cancer therapy
First Claim
1. An ultrasonic energy-activated targeted delivery system that is selectively targeted to a target tissue, comprising:
- (a) an ultrasonic energy-activated agent that absorbs energy and destroys a target tissue to which it is bound; and
(b) a ligand conjugated to the ultrasonic energy-activated agent, the ligand binding to a receptor on the target tissue with specificity, so that binding of the ligand to a non-target tissue is minimized.
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Abstract
The present invention is drawn to delivery systems for administering a therapy to a target tissue or target composition in a mammalian subject, using an ultrasonic energy-activated targeted agent. The claimed energy-activated targeted therapy is useful in the treatment of specifically selected target tissues, such as vascular endothelial tissue, the abnormal vascular walls of tumors, solid tumors of the head and neck, tumors of the gastrointestinal tract, tumors of the liver, tumors of the breast, tumors of the prostate, tumors of the lung, nonsolid tumors, malignant cells of the hematopoietic and lymphoid tissue and other lesions in the vascular system or bone marrow, and tissue or cells related to autoimmune and inflammatory disease.
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Citations
20 Claims
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1. An ultrasonic energy-activated targeted delivery system that is selectively targeted to a target tissue, comprising:
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(a) an ultrasonic energy-activated agent that absorbs energy and destroys a target tissue to which it is bound; and
(b) a ligand conjugated to the ultrasonic energy-activated agent, the ligand binding to a receptor on the target tissue with specificity, so that binding of the ligand to a non-target tissue is minimized. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. An ultrasonic energy-activated targeted delivery system, comprising:
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(a) an ultrasonic energy-activated agent that absorbs energy and destroys a target tissue to which it is bound;
(b) a liposome delivery system; and
(b) a ligand that binds to a receptor on a target tissue with specificity;
wherein the ligand is separately conjugated to the ultrasonic energy-activated agent and to the liposomes of the liposome delivery system to provide dual targeting of the agent to the target tissue. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18, 19, 20)
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Specification