Mucoadhesive drug delivery devices and methods of making and using thereof
First Claim
1. A mucoadhesive device, comprising one or more purified proteins, combined with one or more pharmacologically active agents, one or more mucoadhesive agents and one or more biocompatible solvents to form a coatable composition, wherein the solvent content of the coatable composition is reduced to form a cohesive body or solidified cohesive mass that is formed into a mucoadhesive device having a substantially homogenous distribution of the purified proteins, pharmacologically active agents, mucoadhesive agents and biocompatible solvents.
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Abstract
The present invention relates to mucoadhesive drug delivery devices and their methods of preparation and use. More specifically the present invention relates to mucoadhesive drug delivery devices comprising one or more biocompatible purified proteins combined with one or more biocompatible solvents and one or more mucoadhesive agents. The mucoadhesive drug delivery devices may also include one or more pharmacologically active agents. The drug delivery devices of the present invention adhere to mucosal tissue, thereby providing a vehicle for delivery of the pharmacologically active agent(s) through such tissue.
158 Citations
42 Claims
- 1. A mucoadhesive device, comprising one or more purified proteins, combined with one or more pharmacologically active agents, one or more mucoadhesive agents and one or more biocompatible solvents to form a coatable composition, wherein the solvent content of the coatable composition is reduced to form a cohesive body or solidified cohesive mass that is formed into a mucoadhesive device having a substantially homogenous distribution of the purified proteins, pharmacologically active agents, mucoadhesive agents and biocompatible solvents.
- 19. A mucoadhesive device, comprising ovalbumin, combined with one or more pharmacologically active agents, one or more mucoadhesive agents and one or more biocompatible solvents to form a coatable composition, wherein the solvent content of the coatable composition is reduced to form a cohesive body or solidified cohesive mass that is formed into a mucoadhesive device having a substantially homogenous distribution of the purified proteins, pharmacologically active agents, mucoadhesive agents and biocompatible solvents.
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34. A method of delivering one or more pharmacologically active agents through the mucosal tissue of a patient comprising the steps of:
adhering a mucoadhesive device to the mucosal tissue of a patient, said mucoadhesive device including one or more purified proteins, combined with one or more pharmacologically active agents, one or more mucoadhesive agents and one or more biocompatible solvents to form a coatable composition, wherein the solvent content of the coatable composition is reduced and formed into a mucoadhesive device having a homogenous distribution of the purified proteins, pharmacologically active agents, mucoadhesive agents and biocompatible solvents. - View Dependent Claims (35, 36, 37, 38)
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39. A method of making a mucoadhesive drug delivery device comprising
(a) preparing a coatable composition including the one or more biocompatible purified proteins, one or more biocompatible solvents, one or more mucoadhesive agents and one or more pharmacologically active agents; -
(b) partially drying the coatable composition to reduce bulk solvent present in the system to form a solidified cohesive mass including a substantially homogenous distribution of purified proteins, solvents, mucoadhesive agents and pharmacologically active agents; and
(c) processing the cohesive mass to form a mucoadhesive device. - View Dependent Claims (40, 41, 42)
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Specification