Method and device for monitoring platelet function
First Claim
Patent Images
1. A method of monitoring platelet function comprising:
- passing blood removed from a mammal through a passageway comprising an obstruction or an irregularity, to contact the obstruction or the wall of the passageway at the irregularity, to generate a platelet mass in the passageway; and
monitoring the flow or composition of the blood in the passageway to detect formation of the platelet mass;
wherein the passageway does not comprise an added biological agent that activates platelets.
3 Assignments
0 Petitions
Accused Products
Abstract
The invention provides a method of monitoring platelet function in a mammal by passing blood removed from the body of the mammal through a passageway to contact an obstruction or irregularity in the passageway to generate a platelet mass in the passageway, and monitoring the flow or composition of the blood in the passageway to detect the platelet mass. The flow and composition change in response to the formation of a platelet mass in the passageway. Devices, articles, and kits for performing the methods are also disclosed.
-
Citations
51 Claims
-
1. A method of monitoring platelet function comprising:
-
passing blood removed from a mammal through a passageway comprising an obstruction or an irregularity, to contact the obstruction or the wall of the passageway at the irregularity, to generate a platelet mass in the passageway; and
monitoring the flow or composition of the blood in the passageway to detect formation of the platelet mass;
wherein the passageway does not comprise an added biological agent that activates platelets. - View Dependent Claims (2, 3, 4, 5, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 36, 37, 38, 39, 40, 41, 42)
-
-
6. A method of monitoring platelet function in a mammal comprising:
-
passing blood removed from a mammal through a passageway comprising an obstruction or an irregularity, to contact the obstruction or the wall of the passageway at the irregularity, to generate a platelet mass in the passageway, and monitoring the flow or composition of the blood in the passageway to detect formation of the platelet mass;
wherein the platelet mass is substantially depleted in fibrin in comparison to a natural clot. - View Dependent Claims (7, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35)
-
-
43. A device for monitoring platelet function, comprising:
-
a fluid-tight material forming a passageway;
a pump functionally linked to the passageway for pumping blood through the passageway;
an obstruction within the passageway, arranged such that when blood is pumped through the passageway to contact the obstruction, a platelet mass substantially free of fibrin forms on or near the obstruction; and
a means for detecting the flow of blood through the passageway to detect formation of the platelet mass. - View Dependent Claims (45, 49, 50)
-
-
44. A device for monitoring platelet function, comprising:
-
a fluid-tight material forming a passageway;
a pump functionally linked to the passageway for pumping blood through the passageway;
an obstruction within the passageway, arranged such that when blood is pumped through the passageway to contact the obstruction, a platelet mass substantially free of fibrin forms on or near the obstruction; and
a means for detecting the composition of blood in the passageway to detect formation of the platelet mass.
-
-
46. A device for monitoring platelet function, comprising:
-
a fluid-tight material forming a passageway;
a pump functionally linked to the passageway for pumping blood through the passageway;
wherein the passageway comprises an irregularity arranged such that when blood is pumped through the passageway to contact the wall of the passageway at the irregularity, a platelet mass substantially free of fibrin forms on the wall of the passageway at or near the irregularity; and
a means for detecting the flow of blood through the passageway to detect formation of the platelet mass. - View Dependent Claims (48)
-
-
47. A device for monitoring platelet function, comprising:
-
a fluid-tight material forming a passageway;
a pump functionally linked to the passageway for pumping blood through the passageway;
wherein the passageway comprises an irregularity arranged such that when blood is pumped through the passageway to contact the wall of the passageway at the irregularity, a platelet mass substantially free of fibrin forms on the wall of the passageway at or near the irregularity; and
a means for detecting the composition of blood in the passageway to detect formation of the platelet mass.
-
-
51-62. -62. (canceled)
Specification