System for the prediction, rapid detection, warning, prevention, or control of changes in activity states in the brain of a subject
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Abstract
A system (10) analyzes signals representative of a subject'"'"'s brain activity in a signal processor (12) for information indicating the subject'"'"'s current activity state and for predicting a change in the activity state. One preferred embodiment uses a combination of nonlinear filtering methods to perform real-time analysis of the electro-encephalogram (EEG) or electro-corticogram (ECoG) signals from a subject patient for information indicative of or predictive of a seizure, and to complete the needed analysis at least before clinical seizure onset. The preferred system then performs an output task for prevention or abatement of the seizure, or for recording pertinent data.
332 Citations
48 Claims
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1-40. -40. (canceled)
- 41. A method of validating a prediction or detection of abnormal activity by determining whether said abnormal activity is followed by a drop in signal energy in at least one frequency band, said drop reaching a level indicative of a post-ictal state.
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43. A method of prediction, rapid detection, warning, prevention or control of changes of activity states in the brain of a subject, the method including the step of quantifying seizure onset location.
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44. A method of prediction, rapid detection, warning, prevention or control of changes of activity states in the brain of a subject, the method including the step of quantifying seizure pattern of spread.
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45. A method of prediction, rapid detection, warning, prevention or control of changes of activity states in the brain of a subject, the method including the step of quantifying seizure duration.
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46. A method of prediction, rapid detection, warning, prevention or control of changes of activity states in the brain of a subject, the method including the step of quantifying seizure intensity.
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47. A method of prediction, rapid detection, warning, prevention or control of changes of activity states in the brain of a subject, the method including the step of quantifying seizure time-frequency evolution.
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48. A method of prediction, rapid detection, warning, prevention or control of changes of activity states in the brain of a subject, the method including the step of quantifying frequency of seizure occurrence.
Specification