IMPROVED BUFFER GEL FOR IONTOPHORESIS ELECTRODES
First Claim
1. An iontophoretic device for delivering a medicament to treat an affected area of a living subject'"'"'s body wherein said iontophoretic device is configured for transdermal application, wherein the device comprises:
- a buffering agent associated with a polymeric gel matrix;
wherein the buffering agent further comprises polymers having pendant carboxylic acid moieties which can maintain pH of the gel matrix from approximately 4.1 to approximately 4.9, and, preferably pH 4.5, for iontophoresis applications;
a viscosity enhancer associated with the polymeric gel matrix to temporarily store the medicament in the matrix;
a rehydrating agent associated with the polymeric gel matrix to facilitate homogeneous hydration in the matrix;
a medicament associated with the polymeric gel matrix; and
an active electrode assembly associated with the polymeric gel matrix configured for iontophoretically delivering the medicament to the affected area of the living subject'"'"'s body.
6 Assignments
0 Petitions
Accused Products
Abstract
An iontophoretic delivery device utilizing a polymeric gel matrix to ameliorate pH deviation within the device wherein the pH of the polymeric gel matrix is buffered at select pH ranges in order to reduce skin irritation. The polymeric gel matrix is housed within the iontophoretic delivery device as a buffering agent wherein the matrix provides a suitable physiological pH level above 4.0 and particularly the pH level deviates between approximately 4.1 to approximately 4.9, and preferably at the pH 4.5 for an effective operation of the iontophoretic delivery of a medicament to treat affected areas of a living subject'"'"'s body.
27 Citations
15 Claims
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1. An iontophoretic device for delivering a medicament to treat an affected area of a living subject'"'"'s body wherein said iontophoretic device is configured for transdermal application, wherein the device comprises:
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a buffering agent associated with a polymeric gel matrix;
whereinthe buffering agent further comprises polymers having pendant carboxylic acid moieties which can maintain pH of the gel matrix from approximately 4.1 to approximately 4.9, and, preferably pH 4.5, for iontophoresis applications;
a viscosity enhancer associated with the polymeric gel matrix to temporarily store the medicament in the matrix;
a rehydrating agent associated with the polymeric gel matrix to facilitate homogeneous hydration in the matrix;
a medicament associated with the polymeric gel matrix; and
an active electrode assembly associated with the polymeric gel matrix configured for iontophoretically delivering the medicament to the affected area of the living subject'"'"'s body. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. A method for treating an affected area of a living subject'"'"'s body, wherein the method comprises the steps of:
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associating a medicament with a matrix in an iontophoretic delivery device;
providing an effective amount of pH buffering agents to the matrix;
attaining high buffer capacity by providing a viscosity enhancer to the matrix;
adding a rehydration agent to the matrix to facilitate homogeneous hydration within the matrix;
positioning at least a portion of the iontophoretic device on the affected area of a living subject; and
iontophoretically delivering the medicament to the affected area of the living subject to minimize skin inflammation. - View Dependent Claims (11, 12, 13, 14, 15)
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Specification