Methods for coating and impregnating medical devices with antiseptic compositions

• US 20050197634A1
• Filed: 01/19/2005
• Published: 09/08/2005
• Est. Priority Date: 01/20/2004
• Status: Abandoned Application

• Current Assignee: Board of Regents of the University of Texas System (University of Texas System)
• Original Assignee: Board of Regents of the University of Texas System (University of Texas System)
• Inventors: Hanna, Hend A., Chaiban, Gassan, Raad, Issam
• Application Number:
  US11/038,775
• Publication Number:
  US 20050197634A1
• Time in Patent Office: Days
• US Class Current: 604/265
• CPC Class Codes: A61L 2300/202 with halogen atoms, e.g. triclosan, povidone-iodine
• CPC Class Codes: A61L 2300/204 with nitrogen-containing functional groups, e.g. aminoxides, nitriles, guanidines
• CPC Class Codes: A61L 2300/206 Biguanides, e.g. chlorohexidine
• CPC Class Codes: A61L 2300/404 Biocides, antimicrobial agents, antiseptic agents
• CPC Class Codes: A61L 2300/442 Colorants, dyes
• CPC Class Codes: A61L 2300/45 Mixtures of two or more drugs, e.g. synergistic mixtures
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: A61L 29/16 Biologically active materials, e.g. therapeutic substances A61L29/048 takes precedence
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: D06P 1/90 using dyes dissolved in organic solvents or aqueous emulsions thereof D06P1/94 takes precedence
• CPC Class Codes: D06P 1/924 Halogenated hydrocarbons
• CPC Class Codes: D06P 1/928 Solvents other than hydrocarbons

Abstract

The present invention provides methods of coating or impregnating medical devices with an antiseptic composition that will inhibit or prevent the nosocomial infections typically associated with the use of such medical devices. The present invention further provides methods of coating or impregnating medical devices that produce devices with effective activity against infection, while avoiding destroying the devices or causing the devices to become toxic. In addition, the invention provides medical devices coated or impregnated with antiseptic compositions by the aforementioned novel methods.

Claims

1. A method for coating or impregnating a medical device with an antiseptic composition comprising:

a) contacting said medical device for no more than about 10 minutes with a solvent comprising a basic reagent and a dye; and

b) drying the device.

2. The method of claim 1, wherein said contacting occurs for no more than about 5 minutes.

3. The method of claim 1, further comprising the step of washing off excessive solvent from the medical device.

4. The method of claim 1, wherein the medical device is contacted with the solvent for about 1 minute.

5. The method of claim 1, wherein the medical device is immersed in the solvent and immediately removed.

6. The method of claim 1, wherein the medical device is sprayed with the solvent.

7. The method of claim 1, wherein the basic reagent and the dye are bonded.

8. The method of claim 7, wherein the basic reagent and the dye are bound ionically.

9. The method of claim 7, wherein the basic reagent and the dye are bound covalently.

10. The method of claim 1, wherein the dye is a triarylmethane dye.

11. The method of claim 1, wherein the dye is a monoazo dye.

12. The method of claim 1, wherein the dye is a diazo dye.

13. The method of claim 1, wherein the dye is an indigoid dye.

14. The method of claim 1, wherein the dye is a xanthene dye.

15. The method of claim 1, wherein the dye is an anthraquinone dye.

16. The method of claim 1, wherein the dye is a quinoline dye.

17. The method of claim 1, wherein the dye is gentian violet or crystal violet, ethyl violet, brilliant green, an FD&

C dye, or a D&

C dye.

18. The method of claim 17, wherein the FD&

C dye is Blue No. 1 or Green No. 3.

19. The method of claim 10, wherein the triarylmethane dye is gentian violet.

20. The method of claim 11 wherein the monoazo dye is FD&

C Yellow No. 5 or D&

C Yellow No. 6.

21. The method of claim 12, wherein the diazo dye is D&

C Red No. 17.

22. The method of claim 13, wherein the indigoid dye is FD&

C Blue No. 2.

23. The method of claim 14, wherein the xanthene dye is FD&

C Red No. 3.

24. The method of claim 15, wherein the anthraquinone dye is D&

C Green No. 6.

25. The method of claim 16, wherein the quinoline dye is D&

C Yellow No. 1.

26. The method of claim 1, wherein the basic reagent is a guanidium compound, a biguanide, a bipyridine, a phenoxide antiseptic, an alkyl oxide, an aryl oxide, a thiol, a halide, an aliphatic amine, EDTA or an aromatic amine.

27. The method of claim 26, wherein the basic reagent is a guanidium compound.

28. The method of claim 27, wherein the guanidium compound is chlorhexidine.

29. The method of claim 27, wherein the guanidium compound is alexidine.

30. The method of claim 27, wherein the guanidium compound is hexamidine.

31. The method of claim 26, wherein the basic reagent is a bipyridine.

32. The method of claim 31, wherein the bipyridine is octenidine.

33. The method of claim 26, wherein the basic reagent is a phenoxide antiseptic.

34. The method of claim 33, wherein the phenoxide antiseptic is clofoctol.

35. The method of claim 33, wherein the phenoxide antiseptic is chloroxylenol.

36. The method of claim 33, wherein the phenoxide antiseptic is triclosan.

37. The method of claim 1, wherein the antiseptic composition is gendine, genlenol, genlosan, or genfoctol.

38. The method of claim 1, wherein the medical device is composed of latex, latex-silicone or silicone.

39. The method of claim 1, wherein the medical device is composed of polyurethane.

40. The method of claim 1, wherein the medical device is composed of polyvinyl chloride.

41. The method of claim 1, wherein the solvent comprises methylene chloride, methanol, or a combination thereof.

42. A medical device coated or impregnated with an antiseptic composition by a process comprising:

a) contacting said medical device for no more than about 10 minutes with a solvent comprising a basic reagent and a dye; and

b) drying the device.

43-85. -85. (canceled)