Vaginal ring preparation and its application
First Claim
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1. A vaginal controlled drug delivery device comprising:
- a tubular base of an inert rubber composition having an outer surface;
a mixture comprising a drug to be delivered, at least one surfactant and at least on dispersing agent applied to said outer surface of said tubular base in a first layer having a thickness from 0.3 mm to 3 mm, and a second layer of silicone rubber having a thickness from 0.02 to 1 mm covering said first layer on said tubular base whereby said drug will diffuse through said second layer when the device is inserted into the vagina at a more controlled rate over time.
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Abstract
A vaginal drug delivery device includes a tubular base of an inert rubber composition, a first layer having a thickness up to 3 mm composed of a mixture of a drug to delivered, at least one surfactant and at least one dispersing agent applied to said outer surface of the tubular base, and a second layer of silicone rubber having a thickness up to 1 mm encapsulating the first layer on the tubular base whereby said drug will diffuse through said second layer when the device is inserted into the vagina to treat the patient with the drug in the first layer.
27 Citations
11 Claims
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1. A vaginal controlled drug delivery device comprising:
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a tubular base of an inert rubber composition having an outer surface;
a mixture comprising a drug to be delivered, at least one surfactant and at least on dispersing agent applied to said outer surface of said tubular base in a first layer having a thickness from 0.3 mm to 3 mm, and a second layer of silicone rubber having a thickness from 0.02 to 1 mm covering said first layer on said tubular base whereby said drug will diffuse through said second layer when the device is inserted into the vagina at a more controlled rate over time. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. A method of controlled vaginal delivery of drugs through gradual release comprising the steps of:
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forming an inert base of a rubber composition;
applying a first layer on said inert base composed of a mixture of a drug to be administered, a surfactant and a dispersing agent, said first layer having a thickness less than 3 mm;
encapsulating said first layer with a second layer of s silicone rubber between said second layer and said inert base, said second layer having a thickness of less than 1 mm; and
inserting said device into the vaginal cavity of a patient to be treated with the drug whereby the dosage of the drug delivered is more uniformly controlled over time at higher concentrations. - View Dependent Claims (11)
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Specification