Pharmaceutical compositions
First Claim
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1. A pharmaceutical composition for a chewable tablet, comprising in admixture:
- an alginic acid or a salt thereof;
a water-soluble carbonate radical precursor;
a calcium salt;
a first bulk sweetener;
a binding agent; and
wherein said calcium salt and either or both of said first bulk sweetener and said binding agent are blended via wet granulation prior to admixture with said alginic acid or salt thereof and said carbonate radical precursor.
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Abstract
A pharmaceutical composition in the form of a chewable tablet for the suppression of gastric reflux comprising an alginic acid or salt thereof, a water-soluble carbonate radical precursor, a calcium salt, a first bulk sweetener, and a binding agent. The calcium salt and either or both of the bulk sweetener and the binding agent may be blended via any of wet granulation, spray drying, or compression processes prior to admixture with the alginic acid and the carbonate radical precursor.
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Citations
216 Claims
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1. A pharmaceutical composition for a chewable tablet, comprising in admixture:
- an alginic acid or a salt thereof;
a water-soluble carbonate radical precursor;
a calcium salt;
a first bulk sweetener;
a binding agent; and
wherein said calcium salt and either or both of said first bulk sweetener and said binding agent are blended via wet granulation prior to admixture with said alginic acid or salt thereof and said carbonate radical precursor. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 63, 152, 159, 160, 161, 162)
- an alginic acid or a salt thereof;
- 59. A pharmaceutical composition comprising calcium carbonate, sugar, mannitol, corn starch, alginic acid, and a carbonate radical precursor selected from the group consisting of potassium bicarbonate, sodium bicarbonate and a combination thereof, wherein the composition is in the form of a chewable tablet.
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64. A pharmaceutical composition for a chewable tablet formed by a process comprising the following steps:
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providing an alginic acid or a salt thereof;
providing a water-soluble carbonate radical precursor;
providing a calcium salt;
providing a first bulk sweetener;
providing a binding agent;
mixing said calcium salt and either or both of said bulk sweetener and said binding agent via wet granulation to form a mixture; and
blending said mixture with said alginic acid or salt thereof, said carbonate radical precursor, and with either said first bulk sweetener or said binding agent if not previously mixed with the calcium salt. - View Dependent Claims (65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 154)
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78. A pharmaceutical composition for a chewable tablet, comprising in admixture:
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an alginic acid or a salt thereof;
a water-soluble carbonate radical precursor;
a calcium salt;
a first bulk sweetener; and
a binding agent. - View Dependent Claims (79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 155)
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92. A pharmaceutical composition, comprising in admixture:
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an alginic acid or a salt thereof;
a water-soluble carbonate radical precursor;
a calcium salt; and
a first bulk sweetener, wherein the composition is in powder form. - View Dependent Claims (93, 94, 95, 96, 97, 98, 99, 100, 101, 102, 103, 104, 105, 106, 156)
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107. A pharmaceutical composition, comprising in admixture:
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an alginic acid or a salt thereof;
a water-soluble carbonate radical precursor;
a calcium salt;
a first bulk sweetener; and
water, wherein the composition is in liquid form. - View Dependent Claims (108, 109, 110, 111, 112, 113, 114, 115, 116, 117, 118, 119, 120, 121, 157)
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122. A pharmaceutical composition for a chewable tablet, comprising in admixture:
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an alginic acid or a salt thereof;
a water-soluble carbonate radical precursor;
a calcium salt;
a first bulk sweetener;
a binding agent; and
wherein said calcium salt and either or both of said first bulk sweetener and said binding agent are blended via spray drying prior to admixture with said alginic acid or salt thereof and said carbonate radical precursor. - View Dependent Claims (123, 124, 125, 126, 127, 128, 129, 130, 131, 132, 133, 134, 135, 136, 158)
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137. A pharmaceutical composition for a chewable tablet, comprising in admixture:
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an alginic acid or a salt thereof;
a water-soluble carbonate radical precursor;
a calcium salt;
a first bulk sweetener;
a binding agent; and
wherein said calcium salt and either or both of said first bulk sweetener and said binding agent are blended via compression prior to admixture with said alginic acid or salt thereof and said carbonate radical precursor. - View Dependent Claims (138, 139, 140, 141, 142, 143, 144, 145, 146, 147, 148, 149, 150, 151)
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- 163. A pharmaceutical composition for a chewable tablet comprising alginic acid or a salt thereof, sodium or potassium phosphate or a combination thereof, at least one calcium salt, and at least one of a first bulk sweetener, or a binding agent wherein the calcium salt, and bulk sweetener or binding agent prior to admixture with the alginic acid and carbonate precursor, are combined together by a wet granulation process, and wherein the composition may optionally further comprise at least one of a second bulk sweetener, talc, mineral oil, and an alkali metal salt of hexametaphosphate, a flavouring agent, an intense sweetener, or a dye.
Specification