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Oral insulin therapies and protocol

  • US 20050203001A1
  • Filed: 03/04/2005
  • Published: 09/15/2005
  • Est. Priority Date: 03/05/2004
  • Status: Abandoned Application
First Claim
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1. A method of treating a diabetic patient, comprising:

  • orally administering to an early stage type II diabetic patient, at a time from about 30 minutes prior to ingestion of a meal to concurrently with ingestion of a meal, a dose of a therapeutically effective amount of unmodified insulin with from about 20 to about 600 mg of a pharmaceutically acceptable delivery agent that facilitates absorption of said insulin from the gastrointestinal tract, said dose contained in one or more pharmaceutically acceptable tablets, to provide a time to maximum plasma concentration of insulin at a time point from about 15 to about 20 minutes after oral administration of said dose, said dose being sufficient to compensate for the lack of a first phase insulin response which occurs endogenously in a non-diabetic subject in response to an ingested meal.

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