Pharmaceutical composition comprising pimobendan
First Claim
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1. A solid formulation, comprising pimobendan or a pharmaceutically acceptable salt thereof which is homogenously dispersed in a polyvalent acid selected from the group consisting of acetic acid, tartaric acid, an anhydride thereof and mixtures thereof, and a flavor suitable for small animals.
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Abstract
The invention relates to novel solid formulations comprising as pharmaceutically active compound pimobendan and to processes for producing such solid formulations. The invention furthermore relates to a method for manufacturing a medicament for the prevention and/or treatment of congestive heart failure, wherein the solid formulations according to the invention are used.
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Citations
17 Claims
- 1. A solid formulation, comprising pimobendan or a pharmaceutically acceptable salt thereof which is homogenously dispersed in a polyvalent acid selected from the group consisting of acetic acid, tartaric acid, an anhydride thereof and mixtures thereof, and a flavor suitable for small animals.
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13. A fluid-bed granulation process comprising the steps of:
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a) spraying an aqueous solution of pimobendan and a binder onto a solid support comprising one or several carriers or excipients, flavor and citric acid anhydride and b) drying the sprayed mixture c) sieving and de-agglomerating the dried mixture d) adding a flow regulator to the resulting mixture e) adding a lubricant to resulting mixture; and
f) blending the resulting mixture for uniformity of granules - View Dependent Claims (14, 15, 16)
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Specification