Method and a device for measuring glucose

• US 20050203361A1
• Filed: 03/02/2005
• Published: 09/15/2005
• Est. Priority Date: 09/04/2002
• Status: Active Grant

• Current Assignee: Solianis Holding AG
• Original Assignee: Pendragon Medical Ltd.
• Inventors: Caduff, Andreas, Feldman, Yuri
• Granted Patent: US 7,184,810 B2
• Time in Patent Office: Days
• US Class Current: 600/347
• CPC Class Codes: A61B 5/05 Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves impedance plethysmography A61B5/0295; measuring movement of the entire body or parts thereof A61B5/11; detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof A61B5/24
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement

Abstract

In order to measure the glucose level in the body tissue of a subject (1), a probe (5) is applied the subject'"'"'s skin. Electric pulses from a pulse generator (2) are fed to the probe and partially reflected back to a measuring device (7), where a time resolved measurement is made. The charge obtained from an integration of the measured voltage is transformed to a glucose level using data from a calibration table (9). This method allows to monitor glucose non-invasively.

Claims

1. A device for measuring a glucose level in a sample comprising

a probe (5) having an end (6) to be applied to the sample,

a pulse generator (2) for generating electric pulses in the probe (5),

a measuring device (7) for measuring pulses reflected from the end of the probe (5), and

an analyzer (8) for determining at least one parameter (Q, V, I_Q, ε

*) of the reflected pulses measured by the measuring device (7) and for determining the glucose level from said parameter.

2. The device of claim 1, having a memory (9) for storing calibration data for transforming the at least one parameter to the glucose level.

3. The device of claim 1, wherein the reflection measuring device (7) carries out a time resolved measurement of the reflected pulses.

4. The device of claim 1, wherein the reflection measuring device (7) carries out at least one measurement in a period of 10 to 1000 ns after generating a pulse in the pulse generator.

5. The device of claim 1, wherein the pulses generated by the pulse generator (2) have rise and/or fall times of less than 1 ns, and a duration of at least 10 ns.

6. The device of claim 1, wherein the parameter is an integral over a period of time of a voltage (V) including the reflected pulse, and in particular wherein the period of time ends less than 100 ns after generating the corresponding pulse in the pulse generator.

7. The device of claim 6, wherein the integral starts less than 1 ns after generating the corresponding pulse in the pulse generator, and in particular wherein the integral starts when generating the corresponding pulse in the pulse generator.

8. The device of claim 1, wherein the parameter is a value of a voltage (V) including the reflected pulse measured at a given time after generating the corresponding pulse in the pulse generator.

9. The device of claim 1, wherein the parameter is a difference of two voltages including the reflected pulse measured at different times (t1, t2) after generating the corresponding pulse in the pulse generator.

10. The device of claim 1, wherein the parameter is a slope of a voltage (V) including the reflected pulse measured at a given time after generating the corresponding pulse in the pulse generator.

11. A method for measuring a glucose level in a sample comprising

applying an end (6) of a probe (5) to the sample,

feeding electric pulses to the probe (5),

measuring a voltage (V) depending on pulses reflected from the end of the probe (5), and

determining at least one parameter (Q, V, IQ, ε

*) of the voltage and determining the glucose level from said parameter.