Methods and devices for plasmon enhanced medical and cosmetic procedures

• US 20050203495A1
• Filed: 08/12/2004
• Published: 09/15/2005
• Est. Priority Date: 03/10/2004
• Status: Abandoned Application

• Current Assignee: US. Patent & Trademark Office (Government of the United States of America)
• Original Assignee: American Environmental Systems, Inc.
• Inventors: Malak, Henryk
• Application Number:
  US10/916,560
• Publication Number:
  US 20050203495A1
• Time in Patent Office: Days
• US Class Current: 606/9
• CPC Class Codes: A61B 18/203 applying laser energy to the outside of the body
• CPC Class Codes: A61B 2018/0047 Upper parts of the skin, e.g. skin peeling or treatment of wrinkles
• CPC Class Codes: A61K 2800/413 Nanosized, i.e. having sizes below 100 nm
• CPC Class Codes: A61K 2800/624 by macromolecular compounds
• CPC Class Codes: A61K 2800/81 Preparation or application process involves irradiation
• CPC Class Codes: A61K 8/0241 Containing particulates characterized by their shape and/or structure see also A61K8/04, A61K8/11, and A61K8/14, further aspects are classified in A61K2800/40 and subcodes
• CPC Class Codes: A61K 8/72 containing organic macromolecular compounds
• CPC Class Codes: A61N 5/062 Photodynamic therapy, i.e. excitation of an agent
• CPC Class Codes: A61Q 1/145 Tattoo removal
• CPC Class Codes: A61Q 19/02 for chemically bleaching or whitening the skin
• CPC Class Codes: A61Q 9/04 Depilatories

Abstract

Composition of methods and devices for surface plasmon resonance-enhanced medical and cosmetic procedures are disclosed. The invention relates to the use of a nonlinear surface plasmon resonance generation source and metal nanoparticles embedded to a body to enhance medical and cosmetic procedures in the body. The methods and devices in this invention can be applied for very effective three-dimensionally localized body surgery, tattoo removal, skin pigmentation removal, hair removal, drug delivery, photodynamic therapy, thrombosis, lithotripsy and cosmetic body treatment. The present invention relates also to a method of making temporary, semi-permanent and permanent tattoos with surface plasmon resonance technique.

Claims

1. A method and a device for a surface plasmon resonance enhanced body surgery, tattoo and skin pigmentation removal, hair removal, thrombosis, lithotripsy, drug delivery, photodynamic therapy and cosmetic body treatment comprising of:

a. a targeted body;

b. an embedded nanoparticle in said targeted body;

c. a nonlinear excitation surface plasmon resonance source exciting said embedded nanoparticle and irradiating said targeted body;

d. a surface plasmon resonance excited embedded nanoparticle causing biochemical changes in said targeted body;

e. a device is comprised of said nonlinear excitation surface plasmon resonance source, a delivery system of irradiation from nonlinear excitation surface plasmon resonance source to said targeted body and said embedded nanoparticles, a feedback system to monitor said targeted body, software and electronics.

2. A method and a device claimed in claim 1, wherein said targeted body is a human body, animal body.

3. A method and a device claimed in claim 1, wherein said targeted body is a tissue containing a tattoo ink, tissue containing pigmentation, abnormal tissue, soft tissue, hard tissue, cell, body fluid, non-cellular and non-tissue material.

4. A method and a device claimed in claim 1, wherein said embedded nanoparticle is a metal, metallic composite, metal oxide, metallic salt, electric conductor, electric superconductor, electric semiconductor, dielectric, quantum dot, metal and dielectric composite, metal and semiconductor composite, metal and semiconductor and dielectric composite.

5. A method of claim 4, wherein said embedded nanoparticle has optical absorption within the range of 200 nm to 10,000 nm.

6. A method of claim 4, wherein said embedded nanoparticle is an uncoated nanoparticle, coated nanoparticle.

7. A method of claim 6, wherein said coated nanoparticle has a coat made of a biorecognitive material, bioactive material, biological material, biocide material, dielectric material, chemorecognitive material, chemical active material, polymer, environmentally sensitive polymer, hydrogel, another layer of metal, another layer of semiconductor, another layer of dielectric, composition of metal and semiconductor and dielectric layers, polymer material containing a drug, polymer containing a tattoo ink, polymer containing a fluorescent marker, thermally sensitive material containing a drug, thermally sensitive material containing a tattoo ink, thermally sensitive material containing a fluorescent marker, thermally sensitive material containing a chemical substance.

8. A method and a device claimed in claim 1, wherein said embedded nanoparticle is a complex of said nanoparticle and a tattoo ink molecule bounded by a chemical linker of a length within a range of 0 nm and 10,000 nm.

9. A method and a device claimed in claim 1, wherein said embedded nanoparticle is a mixture of said nanoparticle and a tattoo ink molecule where a distance between them is within a range of 0 nm and 10,000 nm.

10. A method of claim 4, wherein said embedded nanoparticle size is within the range of 0.1 nm to 50,000 nm in at least one of the dimensions.

11. A method of claim 4, wherein said embedded nanoparticle is a thin film, colloid, fiber, nanoisland, nanowire, shell.

12. A method and a device claimed in claim 1, wherein said embedded nanoparticles are placed in said targeted body by an injection, ingestion, inhalation, adsorption, absorption, direct contact.

13. A method and a device claimed in claim 1, wherein said nonlinear excitation surface plasmon resonance source is a CW optical source, pulsed optical source.

14. A method of claim 13, wherein said optical source is selected from the group consisting of a laser, ion laser, semiconductor laser, Q-switched laser, free-running laser, fiber laser, light emitted diode, lamp, sun, fluorescence, electroluminescence.

15. A method of claim 14, wherein said optical source is a single wavelength polarized optical source at wavelength within the range of 200 nm to 10,000 nm, single wavelength unpolarized optical source at wavelength within the range of 200 nm to 10,000 nm.

16. A method of claim 14, wherein said optical source is a plurality wavelength polarized optical source at wavelengths within the range of 200 nm to 10,000 nm, plurality wavelength unpolarized optical source at wavelengths within the range of 200 nm to 10,000 nm.

17. A method of claim 14, wherein said pulsed optical source generates pulses at frequencies within the range of 1 Hz to 1 THz.

18. A method of claim 17, wherein said pulsed optical source generates an attosecond pulse, femtosecond pulse, nanosecond pulse, microsecond pulse, millisecond pulse.

19. A method and a device claimed in claim 1, wherein said nonlinear excitation surface plasmon resonance source is electromagnetic radiation, ultrasound, thermal energy, electrical energy, magnetic energy, electrostatic energy.

20. A method and a device claimed in claim 1, wherein said nonlinear excitation surface plasmon resonance source is irradiating said embedded nanoparticles and said targeted body with intensity within the range of 0.00005 mW/cm² to 1000 TW/cm².

21. A method and a device claimed in claim 1, wherein said nonlinear excitation surface plasmon resonance source generates surface plasmons in said embedded nanoparticles in a two-photon mode, multi-photon mode, step-wise mode, up-conversion mode.

22. A method and a device claimed in claim 1, wherein said nonlinear excitation surface plasmon resonance source generates surface plasmons in said embedded nanoparticles in a one-photon mode.

23. A method and a device claimed in claim 1, wherein said delivery system of irradiation from nonlinear excitation surface plasmon resonance source to said targeted body and said embedded nanoparticles is by a laser, fiber, waveguide, fiber and a contact tip, waveguide and a contact tip.

24. A method of claim 4 and claim 24, wherein said delivery system on a distal end directly contacting with said targeted body is covered with said thin film with nanoparticles.

25. A method and a device claimed in claim 1, wherein said feedback system is monitoring light, ultrasound, electric energy, magnetic energy and thermal energy from said embedded nanoparticles and said targeted body.

26. Methods of claim 25, wherein said light monitored from said targeted body is fluorescence, light scattering, fluorescence polarization, fluorescence spectrum, reflection, reflection spectrum, Raman spectrum, electroluminescence, bioluminescence, chemiluminescence.

27. A method and a device claimed in claim 1, wherein said device is a catheter, endoscope, laser surgery device.

28. A method and a device claimed in claim 1, wherein said embedded nanoparticles are used as an anti-bacterial agent in said targeted body.

29. A method and a device claimed in claim 1, wherein said surface plasmon resonance enhanced body surgery, tattoo and skin pigmentation removal, hair removal, thrombosis, lithotripsy, drug delivery, photodynamic therapy and cosmetic body treatment is a three-dimensionally localized.

32. Methods of claim 4, claim 7, claim 8 and claim 9 are used to make an erasable tattoo, semi-permanent tattoo, permanent tattoo.

33. Methods and a device claimed in claim 1 and claim 32 are used to remove an erasable tattoo, semi-permanent tattoo, permanent tattoo.