Structures and devices for parenteral drug delivery and diagnostic sampling
First Claim
1. A device for implantation within a subject, comprising:
- a rigid structure having at least first and second surfaces, wherein at least the first surface has a predefined pattern of ingrowth features configured to promote tissue ingrowth;
an interior lumenal space at least partially defined by the second surface of the rigid structure; and
a predefined pattern of passages extending between the first surface and the second surface of the rigid structure, such that the interior lumenal space can be placed in fluid communication with tissue of the subject.
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Abstract
A structure for and method of manufacture of structures for implantation within the tissue of a mammalian subject are disclosed. These structures can be utilized in applications such as the delivery of therapeutic drugs to the tissue of the subject or the sampling of biofluids for the purposes of diagnosis. In one embodiment of the invention, a rigid structure has defined ingrowth features on a surface intended to contact tissue of the subject and defined passage features which provide a fluid path from the surface intended to contact tissue to another surface. The dimensions of these defined features vary based on the particular application, as the ingrowth features are of a dimension and spacing to promote ingrowth of the surrounding tissue, and the passage features are of a dimension to inhibit the passage through the structure of cells from the surrounding tissue.
50 Citations
41 Claims
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1. A device for implantation within a subject, comprising:
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a rigid structure having at least first and second surfaces, wherein at least the first surface has a predefined pattern of ingrowth features configured to promote tissue ingrowth;
an interior lumenal space at least partially defined by the second surface of the rigid structure; and
a predefined pattern of passages extending between the first surface and the second surface of the rigid structure, such that the interior lumenal space can be placed in fluid communication with tissue of the subject. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A rigid structure for implantation within a subject, comprising:
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a first surface, said first surface comprising a predefined pattern of ingrowth features extending outward from said first surface, configured to contact tissue within the subject and promote tissue ingrowth;
a second surface; and
a predefined pattern of passages extending from the first surface to the second surface, wherein the passages are of sufficiently small dimension to preclude mammalian cellular passage via the passages. - View Dependent Claims (13, 14, 15, 16, 17, 18, 19, 20)
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21. A method of manufacturing a rigid structure for use in a device implantable within the tissue of a subject, comprising:
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selectively removing material from a structure in order to create a predefined pattern of passage features having at least one dimension sufficiently small to preclude mammillian cellular passage; and
selectively removing material from a first surface of the structure in order to create a predefined pattern of ingrowth features configured to promote tissue ingrowth. - View Dependent Claims (22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32)
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- 33. A method of manufacturing a rigid structure for use in a device implantable within the tissue of a subject, comprising selectively depositing material in order to create a structure comprising a predefined pattern of passage features and ingrowth features, wherein the passage features have at least one dimension sufficiently small to preclude mammillian cellular passage, and wherein the ingrowth features are configured to promote tissue ingrowth.
Specification