Compositions and methods for prevention of photoaging

• US 20050208000A1
• Filed: 02/17/2005
• Published: 09/22/2005
• Est. Priority Date: 02/22/1999
• Status: Abandoned Application

• Current Assignee: GTC Biotherapeutics, Inc.
• Original Assignee: GTC Biotherapeutics, Inc.
• Inventors: Bernstein, Eric F., Forbes, Paul Donald, Echelard, Yann
• Application Number:
  US11/060,041
• Publication Number:
  US 20050208000A1
• Time in Patent Office: Days
• US Class Current: 424/59
• CPC Class Codes: A61K 2800/522 Antioxidants; Radical scavengers
• CPC Class Codes: A61K 2800/782 Enzyme inhibitors; Enzyme antagonists
• CPC Class Codes: A61K 38/57 from animals; from humans A61K38/553, A61K38/556 take precedence
• CPC Class Codes: A61K 8/64 Proteins; Peptides; Derivatives or degradation products thereof
• CPC Class Codes: A61K 8/986 Milk; Derivatives thereof, e.g. butter
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61P 17/02 for treating wounds, ulcers, burns, scars, keloids, or the like
• CPC Class Codes: A61P 17/16 Emollients or protectives, e.g. against radiation
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: A61P 39/06 Free radical scavengers or antioxidants
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: A61Q 17/04 Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
• CPC Class Codes: A61Q 19/08 Anti-ageing preparations

Abstract

Methods of preventing photoaging and other types of sun damage by topically applying a composition containing a serine protease inhibitor or milk are provided. Pharmaceutical compositions comprising serine protease inhibitors or milk for the prevention of photoaging and other types of sun damage are also provided.

Claims

1. :

A method of protecting humans against photoaging, sunburn and skin cancer caused by solar radiation comprising topically applying to skin of a human prior to exposure of the skin to solar radiation a serine protease inhibitor in an amount effective to protect the skin against photoaging, sunburn and skin cancer.

2. :

The method of claim 1 wherein the serine protease inhibitor is alpha 1-antitrypsin.

11. :

The method of claim 1 wherein milk comprising recombinantly expressed serine protease inhibitor is topically applied to the skin.

3-4. -4. (canceled)

5. :

A method of protecting individuals with a heightened sensitivity to the sun from damage resulting from the sun comprising topically applying to the skin of an individuals with a heightened sensitivity to the sun a serine protease inhibitor prior to exposure of the individual to the sun.

6. :

The method of claim 5 wherein the serine protease inhibitor is alpha 1-antitrypsin.

12. :

The method of claim 5 wherein milk comprising recombinantly expressed serine protease inhibitor is topically applied to the skin.

7. :

A method of protecting humans exposed to sunlight against photoaging, sunburn and skin cancer comprising topically applying to skin of a human milk or a product derived from milk.

8-9. -9. (canceled)

10. :

A pharmaceutical composition for prevention of photoaging and other sun-damage comprising milk and a pharmaceutical additive.