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Oral administration of therapeutic agent coupled to transporting agent

  • US 20050208032A1
  • Filed: 01/18/2005
  • Published: 09/22/2005
  • Est. Priority Date: 01/16/2004
  • Status: Abandoned Application
First Claim
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1. A process for production of insulin in a diabetic mammal by provision of a transdifferentiating moiety including at least one homeogene operably linked to a promoter, which induces transdifferentiation of host cells in vivo to instigate the formation of insulin producing cells comprising:

  • providing at least one transporting agent effective for enabling widespread distribution, systemic expression and sustained delivery of said transdifferentiating moiety via said natural gastrointestinal pathway;

    forming a distributable moiety by coupling said transporting agent, at least one compound effective for protecting said transdifferentiating moiety within said natural gastrointestinal pathway, and said transdifferentiating moiety in a manner effective to enable widespread distribution, systemic delivery and sustained expression upon intracellular absorption via said natural gastrointestinal pathway;

    orally administering said distributable moiety by way of a natural gastrointestinal pathway;

    transporting said distributable moiety in vivo via said natural gastrointestinal pathway, whereby said transdifferentiating moiety is included within essentially all cells of said subject; and

    transdifferentiating host cells to instigate the formation of insulin producing cells, whereby insulin is produced by said mammal in amounts effective to achieve controlled glycemia.

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