Thioredoxin increases redox-cycling of anticancer agents thereby sensitizes cancer cells to apoptosis
First Claim
1. A method of treating a subject comprising administering to the subject a therapeutically effective amount of a thioredoxin or a thioredoxin-like molecule and providing to the subject an anticancer therapy.
1 Assignment
0 Petitions
Accused Products
Abstract
The present invention provides for treatment of cancer by enhancing the effectiveness of anticancer agents. The present invention therefore provides methods of increasing the apoptotic potential of anticancer drugs by increasing the expression of the cellular redox protein thioredoxin or thioredoxin-like molecules and thereby sensitizing the cancer to the anticancer agent. The present invention also provides methods of ameliorating negative side-effects of an anticancer therapy comprising a thioredoxin or a thioredoxin-like molecule and an anticancer therapy.
13 Citations
54 Claims
- 1. A method of treating a subject comprising administering to the subject a therapeutically effective amount of a thioredoxin or a thioredoxin-like molecule and providing to the subject an anticancer therapy.
- 31. A method of sensitizing a cancer cell to an anticancer agent comprising providing an effective amount of a thioredoxin or a thioredoxin-like molecule and an anticancer therapy to the cancer cell.
-
47. A method of ameliorating negative side-effects of an anticancer therapy in a subject comprising administering to the subject a therapeutically effective amount of a thioredoxin or a thioredoxin-like molecule and an anticancer therapy.
- 48. A pharmaceutical combination comprising a thioredoxin or a thioredoxin-like molecule and an anticancer agent.
Specification