Targeted transscleral controlled release drug delivery to the retina and choroid
First Claim
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1. A method of delivering a nucleic acid molecule into a mammalian eye, the method comprising contacting a scleral surface of the eye with a nucleic acid molecule having a molecular weight no greater than 150 kDa such that the nucleic acid passes through the sclera and into the interior of the eye.
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Abstract
The invention provides methods for delivering a therapeutic or diagnostic agent to the eye of a mammal. The method involves contacting sclera with a therapeutic or diagnostic agent so as to permit its passage through the sclera into the choroidal and retinal tissues. The sclera may be contacted with a therapeutic or diagnostic agent together with a device for enhancing transport of the agent through the sclera.
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37 Claims
- 1. A method of delivering a nucleic acid molecule into a mammalian eye, the method comprising contacting a scleral surface of the eye with a nucleic acid molecule having a molecular weight no greater than 150 kDa such that the nucleic acid passes through the sclera and into the interior of the eye.
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2-20. -20. (canceled)
- 24. A method of delivering a nucleic acid molecule into a mammalian eye, the method comprising contacting a scleral surface of the eye with a nucleic acid molecule having a molecular radius of at least 0.5 nm and a molecular weight no greater than 150 kDa so that the nucleic acid passes through the sclera and into the interior of the eye.
Specification