Branched peptide amphiphiles, related epitope compounds and self assembled structures thereof
First Claim
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1. A non-linear peptide amphiphile compound comprising a peptide component comprising at least one amino acid residue comprising a pendant amino group, said amino group coupled to a component non-linear with said peptide component, said peptide component coupled to a hydrophobic component.
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Abstract
Branched peptide amphiphilic compounds incorporating one or residues providing a pendant amino group for coupling one or more epitope sequences thereto, such compounds and related compositions for enhanced epitope presentation.
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30 Claims
- 1. A non-linear peptide amphiphile compound comprising a peptide component comprising at least one amino acid residue comprising a pendant amino group, said amino group coupled to a component non-linear with said peptide component, said peptide component coupled to a hydrophobic component.
- 14. A system comprising a non-linear peptide amphiphile compound comprising a peptide component, a hydrophobic component coupled to said peptide component, said peptide component comprising at least one amino acid residue comprising a pendant amino group coupled to a bioactive epitope sequence, said compound in a fluid medium.
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21. A method of using a pendant amino group of a peptide amphiphile to present a biologically active epitope sequence, said method comprising:
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providing a plurality of peptide amphiphile compounds, each said compound comprising a hydrophobic component and a peptide component, at least one of said compounds comprising at least one amino acid residue comprising a pendant amino group; and
coupling a biologically active epitope sequence to said amino group. - View Dependent Claims (22, 23, 24, 25, 26, 27, 28, 29, 30)
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Specification