Secreted factors
First Claim
1. An antibody or fragment thereof that specifically binds to an antigen selected from the group consisting of:
- (a) a polynucleotide encoding at least 50 contiguous amino acids from amino acids 1 to 148 of SEQ ID NO;
2;
(b) a polynucleotide encoding a polypeptide having at least 75% sequence identity with amino acids 1 to 203 of SEQ ID NO;
2; and
(c) a polynucleotide of SEQ ID NO;
1.
1 Assignment
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Accused Products
Abstract
The invention concerns new secreted factors encoded by clones P00184-D11 (SEQ ID NO: 1), P00185_D11 (SEQ ID NO: 3), P00188_D12 (SEQ ID NO: 5), P00188_E01 (SEQ ID NO: 7), P00194_G01 (SEQ ID NO: 9), P00194_G05 (SEQ ID NO: 11), P00194_H10 (SEQ ID NO: 13), P00199_D08 (SEQ ID NO: 15), P00203_D04 (SEQ ID NO: 17), P00203_E06 (SEQ ID NO: 19), P00209_F06 (SEQ ID NO: 21), P00219_D02 (SEQ ID NO: 23), P00219_F06 (SEQ ID NO: 25), P00220_H05 (SEQ ID NO: 27), P00222_G03 (SEQ ID NO: 29), P00225_C01 (SEQ ID NO: 32), P00227_D11 (SEQ ID NO: 34), P00228_F03 (SEQ ID NO: 36), P00233_H08 (SEQ ID NO: 38), P00235_008 (SEQ ID NO: 40), P00239_C11 (SEQ ID NO: 42), P00240_E05 (SEQ ID NO: 45), P00247_A04 (SEQ ID NO: 50), P00248_B04 (SEQ ID NO: 52), P00249_F09 (SEQ ID NO: 54), P00258_A10 (SEQ ID NO: 56), P00262_C10 (SEQ ID NO: 58), P00269_H08 (SEQ ID NO: 62), P00628_H02 (SEQ ID NO: 66), P00629_C08 (SEQ ID NO: 68), P00641_G11 (SEQ ID NO: 71), P00648_E12 (SEQ ID NO: 73), P00697_C03 (SEQ ID NO: 75), and other mammalian homologues and variants of such factor, as well as polynucleotides encoding them. The invention further concerns methods and means for producing such factors and their use in the diagnosis and treatment of various cardiac, renal or inflammatory diseases.
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Citations
20 Claims
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1. An antibody or fragment thereof that specifically binds to an antigen selected from the group consisting of:
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(a) a polynucleotide encoding at least 50 contiguous amino acids from amino acids 1 to 148 of SEQ ID NO;
2;
(b) a polynucleotide encoding a polypeptide having at least 75% sequence identity with amino acids 1 to 203 of SEQ ID NO;
2; and
(c) a polynucleotide of SEQ ID NO;
1. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. A composition comprising an antibody or fragment thereof that specifically binds to an antigen selected from the group consisting of:
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(a) a polynucleotide encoding at least 50 contiguous amino acids from amino acids 1 to 148 of SEQ ID NO;
2;
(b) a polynucleotide encoding a polypeptide having at least 75% sequence identity with amino acids 1 to 203 of SEQ ID NO;
2 and(c) a polynucleotide of SEQ ID NO;
1. - View Dependent Claims (9, 10, 11, 12, 13, 14)
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15. A kit comprising:
an antibody or fragment thereof that specifically binds to an antigen selected from the group consisting of a polynucleotide encoding at least 50 contiguous amino acids from amino acids 1 to 148 of SEQ ID NO;
2, a polynucleotide encoding a polypeptide having at least 75% sequence identity with amino acids 1 to 203 of SEQ ID NO;
2 and a polynucleotide of SEQ ID NO;
1.- View Dependent Claims (16, 17, 18, 19, 20)
Specification