Methods and compositions for the treatment of psychiatric conditions

• US 20050209218A1
• Filed: 02/14/2005
• Published: 09/22/2005
• Est. Priority Date: 02/13/2004
• Status: Abandoned Application

• Current Assignee: Adamas Pharmaceuticals, Inc. (Supernus Pharmaceuticals, Inc.)
• Original Assignee: Adamas Pharmaceuticals, Inc. (Supernus Pharmaceuticals, Inc.)
• Inventors: Went, Gregory T., Fultz, Timothy J., Meyerson, Laurence R.
• Application Number:
  US11/058,118
• Publication Number:
  US 20050209218A1
• Time in Patent Office: Days
• US Class Current: 514/220
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/135 having aromatic rings , e.g. ketamine, nortriptyline methadone A61K31/137
• CPC Class Codes: A61K 31/137 Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
• CPC Class Codes: A61K 31/343 condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
• CPC Class Codes: A61K 31/357 having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
• CPC Class Codes: A61K 31/506 not condensed and containing further heterocyclic rings
• CPC Class Codes: A61K 31/55 having seven-membered rings, e.g. azelastine, pentylenetetrazole
• CPC Class Codes: A61K 31/551 having two nitrogen atoms, e.g. dilazep
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61P 25/04 Centrally acting analgesics, e.g. opioids
• CPC Class Codes: A61P 25/08 Antiepileptics; Anticonvulsants
• CPC Class Codes: A61P 25/22 Anxiolytics
• CPC Class Codes: A61P 25/24 Antidepressants
• CPC Class Codes: A61P 25/28 for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: A61P 5/08 for decreasing, blocking or antagonising the activity of the anterior pituitary hormones

Abstract

This invention relates to methods and compositions for treating psychiatric conditions, such as depression.

Claims

1. A pharmaceutical composition comprising:

(a) an NMDA receptor antagonist;

(b) a second agent, wherein said agent is an anti-depressive drug (ADD); and

(c) a pharmaceutically acceptable carrier,

wherein at least one of said NMDA receptor antagonist or said second agent is provided in an extended release dosage form.

2. The pharmaceutical composition of claim 1 wherein said NMDA receptor antagonist has a dC/dT less than about 80% of the rate for the IR formulation.

3. The pharmaceutical composition of claim 1 wherein said NMDA receptor antagonist has a C_max/C_mean of approximately 1.6 or less, approximately 2 hours to at least 12 hours after said NMDA receptor antagonist is introduced into a subject.

4. The pharmaceutical composition of claim 1, wherein the relative Cratio.var of said NMDA receptor antagonist and said second ADD is less than 100% from 2hour to 12 hours post administration.

5. The pharmaceutical composition of claim 1, wherein the relative Cratio.var of said NMDA receptor antagonist and said second ADD is less than 70% of the corresponding IR formulation from 2 hour to 12 hours post administration.

6. The pharmaceutical composition of claim 1, wherein said second agent is a selective serotonin re-uptake inhibitor (SSRI), a serotonin/norepinepherine reuptake inhibitors (SNRI) a tricyclic antidepressant (TCA).

7. The pharmaceutical composition of claim 1, wherein said NMDA receptor antagonist is memantine and said second agent is despramine, escitalopram, paroxetine, venlafaxine, duloxetine, buspirone, or bupropion.

8. The pharmaceutical composition of claim 1, wherein said pharmaceutical composition is formulated for oral, transnasal, parenteral, subtopical transepithelial, transdermal patch, subdermal, or inhalation delivery.

10. The pharmaceutical composition of claim 1, wherein said NMDA receptor antagonist is memantine and said second agent is duloxetine.

9. The pharmaceutical composition of claim 9, wherein said pharmaceutical composition is formulated as a suspension, capsule, tablet, suppository, lotion, or patch.

11. A method of treating a CNS-related condition comprising administering to a subject in need thereof a therapeutically effective amount of a combination comprising an NMDA receptor antagonist and a second agent, wherein said second agent is an AED, wherein said NMDA receptor antagonist is provided in an extended release dosage form.

12. The method of claim 11, wherein said CNS-related condition is epilepsy, seizure disorder, or convulsive disorder.

13. The method of claim 11, wherein said NMDA receptor antagonist and said second agent are administered simultaneously or sequentially.

14. The method of claim 11, wherein said NMDA antagonist and said second agent are administered as a single composition.

15. The method of claim 11, wherein said CNS-related condition is chronic nociceptive pain.

16. The method of claim 11, wherein said NMDA receptor antagonist is memantine and said second agent is duloxetine