Implant scaffold combined with autologous or allogenic tissue

• US 20050209705A1
• Filed: 03/09/2005
• Published: 09/22/2005
• Est. Priority Date: 03/09/2004
• Status: Abandoned Application

• Current Assignee: OsteoBiologics Inc. (Smith & Nephew PLC)
• Original Assignee: OsteoBiologics Inc. (Smith & Nephew PLC)
• Inventors: Dinger, Fred B. III, Niederauer, Gabriele G.
• Application Number:
  US11/076,419
• Publication Number:
  US 20050209705A1
• Time in Patent Office: Days
• US Class Current: 623/23.630
• CPC Class Codes: A61F 2/28 Bones joints A61F2/30
• CPC Class Codes: A61F 2/30756 Cartilage endoprostheses A61F2/3603 takes precedence
• CPC Class Codes: A61F 2002/30535 Special structural features of bone or joint prostheses not otherwise provided for
• CPC Class Codes: A61F 2250/0058 Additional features; Implant or prostheses properties not otherwise provided for
• CPC Class Codes: A61L 27/3604 characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel

Abstract

This invention provides implants comprising tissue having an intercellular matrix anchored to a biocompatible scaffold. The intercellular matrix of the tissue provides a natural medium to facilitate the healing and growth of damaged tissue in a patient. The present invention provides methods of treating damaged tissue in a patient by inserting such implants into the damaged tissue. The implants of the present invention include implants comprising allogenic and/or autologous tissue. The tissue may also be acellular.

Claims

1. An implant comprising:

(a) a biocompatible delivery scaffold comprising a distal end, a proximal end, and a scaffold body made of at least one material layer; and

(b) a tissue layer comprising a sheet of tissue, wherein said first tissue layer is attached to the distal end of said scaffold.

2. The implant of claim 1 where said tissue is allogenic, autologous, or a combination thereof.

3. The implant of claim 1 where said tissue is acellular.

4. The implant of claim 1 where said tissue is dermal tissue, adipose tissue, cartilage tissue or bone tissue.

5. The implant of claim 1 where said tissue is human tissue.

6. The implant of claim 1 where said material layer has a porosity and elasticity similar to cartilage tissue or bone tissue.

7. The implant of claim 1 where said material layer is a synthetic polymer.

8. The implant of claim 1 where said tissue is acellular human dermal tissue, and said material layer has a porosity and elasticity similar to bone tissue or cartilage tissue.

9. The implant of claim 1 where said material layer is a porous, biocompatible, biodegradable fiber-reinforced polymer.

10. The implant of claim 1 further comprising an adhesive between the distal end of said scaffold body and said tissue layer, wherein said adhesive is in physical contact with the distal end of said scaffold body and said tissue layer.

11. The implant of claim 1 further comprising one or more sutures, wherein each suture is placed through a portion of said tissue layer and through the interior of the scaffold body.

12. The implant of claim 9 further comprising one or more pre-formed channels in said scaffold body extending from the proximal end to the distal end.

13. The implant of claim 1 where said delivery scaffold further comprises an annular depression around the scaffold body near the distal end of said scaffold.

14. The implant of claim 11 further comprising a suture attaching said tissue layer to said annular depression.

15. The implant of claim 1 further comprising one or more pins disposed through said tissue layer and into the scaffold body.

16. The implant of claim 1 further comprising a second tissue layer.

17. The implant of claim 16, wherein said second tissue layer is allogenic, autologous, or a combination thereof.

18. The implant of claim 16 where said second tissue layer is acellular.

19. The implant of claim 1 where said scaffold body comprises a second material layer adjacent to and proximal to said material layer.

20. The implant of claim 19 where said material layers comprise porous, biocompatible, biodegradable fiber-reinforced polymers, where the orientation of the fibers in one material layer is perpendicular to the orientation of the fibers in the other material layer.

21. The implant of claim 19 further comprising a snapping mechanism comprising:

(a) a snapping attachment extending from a surface of one material layer; and

(b) a receiving cavity disposed in the other material layer and extending below the surface thereof, said receiving cavity adapted to receive and hold said snapping attachment;

wherein the length of said snapping attachment is the same as the depth of said receiving cavity, so that when said snapping attachment is fully inserted into said receiving cavity, the said surfaces of both material layers contact each other.

33. A method of promoting regeneration of damaged tissue comprising inserting the implant of claim 1 into a defect in said damaged tissue.

34. The method of claim 33 further comprising the step of drilling a hole in the bottom of said defect, where the depth of said hole is equal to the distance from the proximal end to the distal end of said implant.

35. The method if claim 33 wherein the distal surface of said tissue layer is approximately level with the surface of the surrounding native tissue.

22. An implant comprising:

(a) a biocompatible delivery scaffold comprising a distal end, a proximal end, and a scaffold body having a porous material layer; and

(b) minced tissue loaded onto said scaffold body.

23. The implant of claim 22 where said tissue is dermal tissue, cartilage tissue or bone tissue.

24. The implant of claim 22 where said tissue is allogenic, autologous, or a combination thereof.

25. The implant of claim 22 where said tissue is acellular.

26. The implant of claim 22 where said porous material layer is biodegradable.

27. The implant of claim 22 where said porous material layer has a porosity and elasticity similar to cartilage tissue or bone tissue.

28. An implant comprising a biocompatible delivery scaffold having a distal end, a proximal end, and a scaffold body comprising a composite biodegradable polymer containing particulated tissue.

29. The implant of claim 28 where said particulated tissue is allogenic, autologous, or a combination thereof.

30. The implant of claim 28 where said tissue is dermal tissue, cartilage tissue or bone tissue.

31. The implant of claim 28 where said tissue is acellular.

32. The implant of claim 28 where said scaffold body has a porosity and elasticity similar to cartilage tissue or bone tissue.