Use of microfluidic systems in the electrochemical detection of target analytes
First Claim
Patent Images
1. A microfluidic device for the detection of a target analyte in a fluid sample comprising:
- a) a solid support member;
b) a sealing inlet port;
c) a detection chamber formed in said support member;
d) a plurality of detection electrodes positioned in said detection chamber, each comprising a binding ligand; and
, e) a microchannel formed in said support member coupled to and extending between said detection chamber and said sealing inlet port.
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Abstract
The invention relates generally to methods and apparatus for conducting analyses, particularly microfluidic devices for the detection of target analytes.
158 Citations
11 Claims
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1. A microfluidic device for the detection of a target analyte in a fluid sample comprising:
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a) a solid support member;
b) a sealing inlet port;
c) a detection chamber formed in said support member;
d) a plurality of detection electrodes positioned in said detection chamber, each comprising a binding ligand; and
,e) a microchannel formed in said support member coupled to and extending between said detection chamber and said sealing inlet port. - View Dependent Claims (3, 4, 7, 8, 9, 10, 11)
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2. A microfluidic device for the detection of a target analyte in a fluid sample comprising:
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a) a solid support member;
b) a sample inlet port;
c) a detection chamber formed in said support member;
d) a plurality of detection electrodes positioned in said detection chamber, each comprising a binding ligand;
e) a microchannel formed in said support member coupled to and extending between said detection chamber and said sample inlet port; and
,f) a valve, positioned within said microchannel.
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5. A microfluidic device for the detection of a target analyte in a fluid sample comprising:
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a) a solid support;
b) a sample inlet port;
c) a detection chamber formed in said support member;
d) a plurality of detection electrodes positioned in said detection chamber, each comprising a binding ligand;
e) a first microchannel formed in said support member coupled to and extending between said detection chamber and said sample inlet port;
f) a pump for inducing the flow of a sample through said microfluidic device; and
,g) a second microchannel formed in said support member coupled to and extending between said detection chamber and said pump.
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6. A microfluidic device for the detection of a target analyte in a fluid sample comprising:
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a) a solid support;
b) a sample inlet port;
c) a detection chamber formed in said support member;
d) a plurality of detection electrodes positioned in said detection chamber, each comprising a binding ligand;
e) a first microchannel formed in said support member coupled to and extending between said detection chamber and said sample inlet port;
f) a mixing chamber for mixing a sample; and
g) a second microchannel formed in said support member coupled to and extending between said detection chamber and said mixing chamber.
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Specification