Test device for simultaneous measurement of multiple analytes in a single sample
First Claim
1. A device for detecting and measuring the concentrations of multiple analytes present in a single liquid sample, which device comprises a matrix material supported on a rigid to semirigid support material, wherein said matrix material comprises a) a central sample receiving portion, which portion is connected to b) at least two outwardly extending arms along which liquid sample flows outwardly from the central sample receiving portion, wherein c) each separate arm has been prepared by impregnation with reagents needed to conduct a test for the detection and measurement of a predetermined analyte believed to be present in said liquid sample, which reagents react with said analyte to produce a measurable signal that is proportional to the concentration of said analyte in said sample:
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Abstract
The invention consists of a test device for simultaneous measurement of multiple analytes in one sample where the liquid sample is applied to a matrix at the central area of the device which is connected to multiple arms, and each of the arms contains specific reagents in dry form for measurement of a particular analyte. The sample travels from the center uniformly and quickly to the reagent site on each arm and produces a measurable signal that may be a change in electrical charge or current, fluorescence, or, preferably, color. A color change can be detected visually or measured quantitatively using a suitable reflectance meter. The sample may be a small amount of whole blood obtained e.g., from a finger puncture or it may be urine, saliva, any other bodily fluid, environmental water, or any other fluid upon which rapid, simultaneous testing of levels of different components is desired. According to the invention, a disease specific panel for kidney, liver, heart, lipid disorders or for early detection of dysfunction of general health can be performed at or near the patients'"'"' site and can provide instant results. Similarly, rapid simultaneous testing of water samples is desirable under many circumstances.
58 Citations
38 Claims
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1. A device for detecting and measuring the concentrations of multiple analytes present in a single liquid sample, which device comprises a matrix material supported on a rigid to semirigid support material, wherein said matrix material comprises
a) a central sample receiving portion, which portion is connected to b) at least two outwardly extending arms along which liquid sample flows outwardly from the central sample receiving portion, wherein c) each separate arm has been prepared by impregnation with reagents needed to conduct a test for the detection and measurement of a predetermined analyte believed to be present in said liquid sample, which reagents react with said analyte to produce a measurable signal that is proportional to the concentration of said analyte in said sample:
Specification