Sampling device for liquid samples

• US 20050214171A1
• Filed: 05/02/2003
• Published: 09/29/2005
• Est. Priority Date: 05/07/2002
• Status: Active Grant

• Current Assignee: Roche Diagnostics Operations Incorporated (Roche Holding AG)
• Original Assignee: Roche Diagnostics Operations Incorporated (Roche Holding AG)
• Inventors: Unkrig, Volker, Augstein, Manfred, Gerstle, Volker
• Granted Patent: US 8,409,413 B2
• Time in Patent Office: Days
• US Class Current: 422/99
• CPC Class Codes: B01L 2200/026 Fluid interfacing between devices or objects, e.g. connectors, inlet details
• CPC Class Codes: B01L 2300/0636 Integrated biosensor, microarrays
• CPC Class Codes: B01L 2300/069 Absorbents; Gels to retain a fluid
• CPC Class Codes: B01L 2300/0825 Test strips
• CPC Class Codes: B01L 2300/0887 Laminated structure
• CPC Class Codes: B01L 2400/0406 capillary forces
• CPC Class Codes: B01L 3/502715 characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
• CPC Class Codes: G01N 33/54386 Analytical elements

Abstract

A device for sampling liquid samples is provided comprising a capillary-active channel, a sampling site, and a determination site. The capillary-active channel is configured for transporting a sample from the sampling site to the determination site. The capillary-active channel is substantially formed by a carrier, a cover and an intermediate layer located between the carrier and cover. The carrier protrudes beyond the cover in the area of the sampling site. The intermediate layer is displaced towards the back in the direction of the determination site in the area of the sampling site so that the carrier as well as the cover protrude beyond the intermediate layer. The device allows sample to be applied from above onto the exposed area of the carrier in the area of the sampling site and also allows sample to be applied from the side.

Claims

1. A device for sampling liquid samples comprising:

a capillary-active channel;

a sampling site; and

a determination site, wherein

the capillary-active channel is configured for transporting a sample from the sampling site to the determination site;

the capillary-active channel is substantially formed by a carrier, a cover and an intermediate layer located between the carrier and cover where the carrier protrudes beyond the cover in the area of the sampling site, and

the intermediate layer is displaced towards the back in the direction of the determination site in the area of the sampling site so that the carrier as well as the cover protrude beyond the intermediate layer.

2. The device of claim 1, wherein the carrier and intermediate layer, or cover and intermediate layer, or carrier and cover and intermediate layer are manufactured from one piece.

3. The device of claim 1, wherein one or more or all surfaces of the carrier, the cover or the intermediate layer facing the capillary-active channel are hydrophilic.

4. The device of claim 1, wherein the capillary-active channel is widened in the area of the sampling site.

5. The device of claim 4, wherein the capillary-active channel is widened in the area of the sampling site to at least one side edge of the device.

6. The device of claim 5, wherein the capillary-active channel is widened in the area of the sampling site to both side edges of the device.

7. The device of claim 1, wherein the capillary-active channel is substantially widened into a funnel shape.

8. The device of claim 1, wherein a structure configured for receiving excess sample which is not in direct contact with the cover is mounted on the part of the carrier that protrudes beyond the cover in the area of the sampling site.

9. The device of claim 8, wherein the structure configured for receiving excess sample has a lower capillarity than the capillary-active channel.

10. The device of claim 8, wherein the structure configured for receiving excess sample further comprises a capillary-active gap or an absorbent material.

11. The device of claim 9, wherein the structure configured for receiving excess sample further comprises a capillary-active gap or an absorbent material.