Methods of and pharmaceutical compositions for modulating T-lymphocyte adhesion, migration, gene expression and function by Glutamate and analogs thereof
First Claim
1. An assay of determining an effect of Glutamate or a Glutamate analog on a T cell related disease or condition, the assay comprising:
- exposing an organism having the T cell related disease or condition to at least one concentration of Glutamate or the Glutamate analog; and
assessing at least one T cell related symptom in said organism.
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Abstract
Methods and compositions for the direct modulation of T-cell activity by the action of glutamate and glutamate functional analogs, effecting gene expression and cytokine secretion, integrin-mediated adhesion, and chemotactic migration for the treatment of infectious diseases, inhibition and prevention of tumor growth and dissemination, prevention and treatment of neurological disease, psychopathology, neuronal damage in CNS disease, infection and injury, containment of auto-immune and other injurious inflammatory processes, enhancement of anti-tumor immune surveillance and prevention of host rejection of engrafted tissue are disclosed.
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Citations
16 Claims
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1. An assay of determining an effect of Glutamate or a Glutamate analog on a T cell related disease or condition, the assay comprising:
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exposing an organism having the T cell related disease or condition to at least one concentration of Glutamate or the Glutamate analog; and
assessing at least one T cell related symptom in said organism. - View Dependent Claims (2, 3, 4)
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- 5. A method of modulating T cell activity, the method comprising exposing T cells to Glutamate or a T cell activity modulating Glutamate analog.
- 12. A method of upregulating T cell activity in a mammalian subject, the method comprising administering to the subject a therapeutically effective amount of Glutamate or a T cell upregulating Glutamate analog, said amount being sufficient to upregulate T cell activity, thereby upregulating said T cell activity in the mammalian subject.
Specification