Treatments for immune systems disorders

• US 20050214392A1
• Filed: 05/26/2005
• Published: 09/29/2005
• Est. Priority Date: 07/23/2001
• Status: Abandoned Application

• Current Assignee: RiceBran Technologies
• Original Assignee: RiceBran Technologies
• Inventors: Cherukuri, Reddy Sastry V., Cheruvanky, Rukmini, Mazhar, Mohammed, McPeak, Patricia
• Application Number:
  US11/139,205
• Publication Number:
  US 20050214392A1
• Time in Patent Office: Days
• US Class Current: 424/750
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/10 Sulfides; Sulfoxides; Sulfones
• CPC Class Codes: A61K 31/7008 Compounds having an amino group directly attached to a carbon atom of the saccharide radical, e.g. D-galactosamine, ranimustine
• CPC Class Codes: A61K 36/87 Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
• CPC Class Codes: A61K 36/899 Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
• CPC Class Codes: A61P 19/02 for joint disorders, e.g. arthritis, arthrosis
• CPC Class Codes: A61P 19/04 for non-specific disorders of the connective tissue
• CPC Class Codes: A61P 19/10 for osteoporosis
• CPC Class Codes: A61P 25/04 Centrally acting analgesics, e.g. opioids
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 29/02 without antiinflammatory effect
• CPC Class Codes: A61P 3/02 Nutrients, e.g. vitamins, minerals
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

This invention provides methods and formulations for treating disorders of the immune system comprising administering a fortified formulation comprising stabilized rice bran derivative and a fortification agent. Preferred rice bran derivatives are rice bran oil and the solubilized fraction of rice bran. Preferred fortification agents are glucosamine derivative, methylsulfonylmethane, yucca concentrate, and grape seed extract.

Claims

1-47. -47. (canceled)

48. A method for treating a disorder of the immune system in a mammal, said method comprising:

administering a fortified formulation comprising a stabilized rice bran derivative and at least one fortification agent, thereby treating said disorder in said mammal.

49. The method of claim 48, wherein said stabilized rice bran derivative is a member selected from the group consisting of rice bran oil, enzyme-treated stabilized rice bran, a solubilized fraction, and a mixture thereof.

50. The method of claim 48, wherein said fortification agent is a member selected from the group consisting of a glucosamine derivative, methylsulfonylmethane, yucca concentrate, and grape seed extract.

52. The method of claim 48 or 51, wherein said administering comprises ingestion of said fortified formulation.

53. The method of claim 48 or 51, wherein said mammal is a member selected from the group consisting of a human, a horse, a cat, and a dog.

54. The method of claim 53, wherein said disorder of the immune system is an autoimmune disease.

55. The method of claim 54, wherein said autoimmune disease is selected from the group consisting of multiple sclerosis, type-1 diabetes mellitus, Graves'"'"' disease, systemic lupus erythematosus, scleroderma, psoriasis, intestinal bowel disease and celiac disease/gluten sensitivity.

56. The method of claim 55, wherein said mammal is a human.

57. The method of claim 55, wherein said disorder of the immune system is intestinal bowel disease, and wherein said formulation is ingested in the amount of about 2 grams to about 100 grams per day total.

58. The method of claim 48 or 51, wherein said formulation is a member selected from the group consisting of a cream, a capsule, a bar, a powder, a food, a food supplement, a medical food, a liquid, a beverage, an emulsion or mixture thereof.

51. A method for treating a disorder of the immune system in a mammal, said method comprising:

administering a fortified formulation comprising a stabilized rice bran derivative and at least one fortification agent, wherein said fortification agent is a member selected from the group consisting of a glucosamine derivative, methylsulfonylmethane, yucca concentrate, and grape seed extract, wherein said stabilized rice bran derivative is a member selected from the group consisting of rice bran oil, enzyme-treated stabilized rice bran wherein the enzyme is carbohydrate cleaving enzyme, a stabilized rice bran solubilized fraction, and a mixture thereof,

thereby treating said immune system disorder in said mammal.