Method and system for the analysis of saliva using a sensor array
First Claim
1. A method for detecting one or more cardiovascular risk factor analytes in saliva comprising:
- passing saliva over a sensor array, the sensor array comprising;
a supporting member comprising a plurality cavities formed within the supporting member;
a plurality of particles, each particle positioned within a cavity, wherein at least one particle is configured to produce a signal in the presence of a cardiovascular risk factor analyte during use; and
monitoring a spectroscopic change of one or more of the particles as the fluid is passed over the sensor array.
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Abstract
A system for the rapid characterization of analytes in saliva. In one embodiment, a system for detecting analytes includes a light source, a sensor array, and a detector. The sensor array is formed from a supporting member, in which a plurality of cavities may be formed. A series of chemically sensitive particles, in one embodiment, are positioned within the cavities. The particles may produce a signal when a receptor, coupled to the particle, interacts with the cardiovascular risk factor analyte and the particle-analyte complex is visualized using a visualization reagent. Using pattern recognition techniques, the analytes within a multi-analyte fluid may be characterized. In an embodiment, each cavity of the plurality of cavities is designed to capture and contain a specific size particle. Flexible projections may be positioned over each of the cavities to provide retention of the particles in the cavities.
127 Citations
20 Claims
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1. A method for detecting one or more cardiovascular risk factor analytes in saliva comprising:
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passing saliva over a sensor array, the sensor array comprising;
a supporting member comprising a plurality cavities formed within the supporting member;
a plurality of particles, each particle positioned within a cavity, wherein at least one particle is configured to produce a signal in the presence of a cardiovascular risk factor analyte during use; and
monitoring a spectroscopic change of one or more of the particles as the fluid is passed over the sensor array. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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Specification