Analyte sensor, and associated system and method employing a catalytic agent

• US 20050215871A1
• Filed: 12/07/2004
• Published: 09/29/2005
• Est. Priority Date: 02/09/2004
• Status: Active Grant

• Current Assignee: Abbott Diabetes Care Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: Abbott Diabetes Care Incorporated (Abbott Laboratories Incorporated)
• Inventors: Cohen, David C., Heller, Adam, Feldman, Benjamin J., Liu, Zenghe
• Granted Patent: US 8,165,651 B2
• Time in Patent Office: Days
• US Class Current: 600/309
• CPC Class Codes: A61B 5/14514 using means for aiding extraction of interstitial fluid, e.g. microneedles or suction
• CPC Class Codes: A61B 5/14528 invasively
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14865 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
• CPC Class Codes: A61B 5/686 Permanently implanted devices, e.g. pacemakers, other stimulators, biochips A61B5/6861 takes precedence
• CPC Class Codes: C12Q 1/002 Electrode membranes
• CPC Class Codes: C12Q 1/004 mediator-assisted
• CPC Class Codes: C12Q 1/005 involving specific analytes or enzymes including groups of enzymes, e.g. oxydases; C12Q1/004 takes precedence
• CPC Class Codes: C12Q 1/006 for glucose

Abstract

An analyte sensor for use in connection with a biofluid is described. The analyte sensor may comprise any suitable interface between the biofluid and a derivative of the biofluid and any suitable transducer of information concerning an analyte. At least one catalytic agent is provided in a locale or vicinity of the interface. The catalytic agent, such as a proteinaceous agent or a non-proteinaceous, organic-metal agent, is sufficient to catalyze the degradation of reactive oxygen and/or nitrogen species that may be present in the vicinity of the interface. An analyte-sensing kit and a method of sensing an analyte are also described.

Claims

1. An analyte sensor for use in connection with a biofluid, comprising:

a transducer sufficient for generating a signal that corresponds to a concentration of an analyte in a derivative portion of the biofluid when the derivative portion of the biofluid contacts the transducer;

an interface sufficient for passage of the derivative portion of the biofluid toward the transducer when the biofluid contacts the interface; and

an organic-metal catalytic agent disposed in a locale of the interface and sufficient to catalyze the degradation of reactive oxygen species and and/or reactive nitrogen species of biological origin in the biofluid and/or the derivative portion of the biofluid, the agent selected from a proteinaceous catalytic agent, a non-proteinaceous catalytic agent, or any combination thereof.

2. The sensor of claim 1, wherein the sensor is partially implantable in a body.

3. The sensor of claim 1, wherein the sensor is a transcutaneous sensor.

4. The sensor of claim 1, wherein the sensor is fully implantable in a body.

5. The sensor of claim 1, wherein the transducer is an electrochemical transducer.

6. The sensor of claim 1, wherein the interface comprises a membrane that at least partially covers the transducer.

7. The sensor of claim 1, wherein the metal of the organic-metal catalytic agent is manganese.

8. The sensor of claim 1, wherein the catalytic agent is MnTPyP.

9. The sensor of claim 1, wherein the catalytic agent is associated with an outer surface of the sensor.

10. The sensor of claim 1, wherein the catalytic agent is an agent of sensor biocompatibility.

11. The sensor of claim 1, wherein the catalytic agent is an agent of sensor signal quality.

12. The sensor of claim 1, wherein the catalytic agent is an anti-neutrophilic agent.

13. An analyte sensor for use in connection with a biofluid, comprising:

a transducer sufficient for generating a signal that corresponds to a concentration of an analyte in a derivative portion of the biofluid when the derivative portion of the biofluid contacts the transducer;

an interface sufficient for passage of the derivative portion of the biofluid toward the transducer when the biofluid contacts the interface, the interface comprising a dialysis membrane; and

an organic-metal catalytic agent disposed in a locale of the interface and sufficient to catalyze the degradation reactive oxygen species a and/or reactive nitrogen species of biological origin in the biofluid and/or the derivative portion of the biofluid, the agent selected from a proteinaceous catalytic agent, a non-proteinaceous catalytic agent, or any combination thereof.

14. The sensor of claim 13, wherein the transducer is an electrochemical transducer.

15. The sensor of claim 13, wherein the transducer is a viscosimetric transducer.

16. The sensor of claim 13, wherein the dialysis membrane comprises a polymer selected from polyacrylonitride, polyamide, and/or polysulfone.

17. The sensor of claim 13, wherein the dialysis membrane comprises a polymer and the catalytic agent is immobilized relative to the polymer.

18. The sensor of claim 13, wherein the catalytic agent is MnTPyP.

19. The sensor of claim 13, wherein the catalytic agent is an agent of sensor biocompatibility.

20. The sensor of claim 13, wherein the catalytic agent is an agent of sensor signal quality.

21. The sensor of claim 13, wherein the catalytic agent is an anti-neutrophilic agent.

22. An analyte sensor for use in connection with a biofluid, comprising:

a transducer sufficient for generating a signal that corresponds to a concentration of an analyte in a derivative portion of the biofluid when the derivative portion of the biofluid contacts the transducer;

an interface sufficient for passage of the derivative portion of the biofluid toward the transducer when the biofluid contacts the interface; and

an organic-metal catalytic agent disposed in a locale of the interface, the agent selected from a proteinaceous catalytic agent, a non-proteinaceous, organic-metal catalytic agent, or any combination thereof, the agent sufficient to mitigate the recruitment of neutrophils to the locale.

23. An analyte-sensing kit for use in connection with an interface that allows passage of a derivative portion of a biofluid when the biofluid contacts the interface, comprising:

a sensor comprising a transducer sufficient for providing a signal that corresponds to a concentration of an analyte in the derivative portion of the biofluid when the derivative portion of the biofluid contacts the transducer; and

an organic-metal catalytic agent sufficient for application in a locale of the interface sufficient to catalyze the degradation of reactive oxygen species and/or reactive nitrogen species of biological origin in the biofluid and/or the derivative portion of the biofluid, the agent selected from a proteinaceous catalytic agent, a non-proteinaceous catalytic agent, or any combination thereof.

24. The kit of claim 23, further comprising an applicator sufficient for application of the catalytic agent in the locale of the interface.

25. The kit of claim 23, the catalytic agent sufficient for application in the locale of the interface, wherein the interface comprises a cutaneous port.

26. The kit of claim 23, the catalytic agent sufficient for topical application in the locale of the interface.

27. The kit of claim 23, the catalytic agent associated with at least one particle, the particle sufficient for creating the interface upon propulsion into the skin, wherein the interface comprises a cutaneous port.

28. The kit of claim 23, wherein the catalytic agent is MnTPyP.

29. The kit of claim 23, wherein the catalytic agent is an agent of biocompatibility.

30. The kit of claim 23, wherein the catalytic agent is an agent of signal quality.

31. The kit of claim 23, wherein the catalytic agent is an anti-neutrophilic agent.

32. A method of sensing an analyte in a derivative portion of a biofluid, comprising:

allowing the derivative portion of the biofluid to pass through an interface;

providing an organic-metal catalytic agent in a locale of the interface sufficient to catalyze the degradation of reactive oxygen species and/or reactive nitrogen species of biological origin in the biofluid and/or the derivative portion of the biofluid, the agent selected from a proteinaceous catalytic agent, a non-proteinaceous catalytic agent, or any combination thereof; and

generating a signal that corresponds to a concentration of the analyte in the derivative portion of the biofluid.

33. The method of claim 32, wherein the interface comprises a cutaneous port.

34. The method of claim 33, further comprising forming the cutaneous port.

35. The method of claim 34, wherein said forming comprises ultrasonically disrupting a portion of skin.

36. The method of claim 34, wherein said forming comprises iontophoretically drawing the derivative portion of the biofluid out of a portion of skin.

37. The method of claim 34, wherein said forming comprises photothermally disrupting a portion of skin.

38. The method of claim 34, wherein said forming comprises propelling at least one particle into a portion of skin.

39. The method of claim 38, wherein the catalytic agent is associated with the at least one particle.

40. The method of claim 33, wherein the providing comprises providing the catalytic agent topically in the locale of the cutaneous port.

41. The method of claim 33, wherein the providing comprises spraying the catalytic agent onto the locale of the cutaneous port.

42. The method of claim 32, wherein the interface comprises a synthetic membrane.

43. The method of claim 42, wherein the catalytic agent is associated with the synthetic membrane.

44. The method of claim 42, wherein the catalytic agent is covalently associated with the synthetic membrane.

45. The method of claim 32, wherein the catalytic agent is an agent of biocompatibility.

46. The method of claim 32, wherein the catalytic agent is an agent of signal quality.

47. The method of claim 32, wherein the catalytic agent is an anti-neutrophilic agent.

48. A method of making an analyte sensor for use in connection with an interface that allows passage of a derivative portion of a biofluid when the biofluid contacts the interface, comprising:

providing a transducer sufficient for generation of a signal that corresponds to a concentration of an analyte in a derivative portion of the biofluid when the derivative portion of the biofluid contacts the transducer;

providing an organic-metal catalytic agent disposed in a locale of the interface and sufficient to catalyze the degradation of reactive oxygen species and/or reactive nitrogen species of biological origin in the biofluid and/or the derivative portion of the biofluid, the catalytic agent selected from a proteinaceous catalytic agent, a non-proteinaceous catalytic agent, or any combination thereof.