Dynamically optimized multisite cardiac resynchronization device
First Claim
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1. A cardiac device, comprising:
- a plurality of electrodes for disposition near different myocardial regions, wherein each such electrode may be connected to a pulse generator for delivering a pacing pulse and may be connected to a sense amplifier for generating an electrogram signal;
a controller programmed to deliver pacing pulses through one or more electrodes in accordance with a programmed pacing mode;
wherein the controller is programmed to measure the amplitudes of electrograms generated by the plurality of electrodes during a depolarization event.
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Abstract
A cardiac rhythm management device in which amplitudes of electrograms from one or more cardiac sites are measured in order to ascertain the extent of hypertrophy. The device may then pace the heart by delivering pacing therapy in a manner that unloads the hypertrophied myocardium to effect reversal of undesirable remodeling.
103 Citations
20 Claims
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1. A cardiac device, comprising:
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a plurality of electrodes for disposition near different myocardial regions, wherein each such electrode may be connected to a pulse generator for delivering a pacing pulse and may be connected to a sense amplifier for generating an electrogram signal;
a controller programmed to deliver pacing pulses through one or more electrodes in accordance with a programmed pacing mode;
wherein the controller is programmed to measure the amplitudes of electrograms generated by the plurality of electrodes during a depolarization event. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. A method, comprising:
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measuring the amplitudes electrograms at a plurality of myocardial sites during a depolarization event;
disposing a pacing electrode near the myocardial site with the largest electrogram amplitude; and
,delivering pacing therapy in accordance with a programmed pacing mode that pre-excites the myocardial site with the largest electrogram amplitude. - View Dependent Claims (11, 12)
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13. A method for operating a cardiac device, comprising:
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delivering pacing pulses through one or more electrodes in accordance with a programmed pacing mode and pacing configuration;
measuring the amplitudes of electrograms generated by a plurality of electrodes disposed near a plurality of myocardial regions during a depolarization event;
adjusting the pacing mode and/or pacing configuration to deliver pacing pulses in a manner that pre-excites the myocardial region with the largest measured electrogram amplitude relative to other myocardial regions. - View Dependent Claims (14, 15, 16, 17, 18, 19, 20)
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Specification