Medical device applications of nanostructured surfaces
First Claim
1. A method for enhancing osteoblast functions on a surface of a medical device implant comprising providing a medical device implant comprising a plurality of nanofibers grown thereon and exposing said medical device implant to osteoblast cells.
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Abstract
This invention provides novel nanofiber enhanced surface area substrates and structures comprising such substrates for use in various medical devices, as well as methods and uses for such substrates and medical devices. In one particular embodiment, methods for enhancing cellular functions on a surface of a medical device implant are disclosed which generally comprise providing a medical device implant comprising a plurality of nanofibers (e.g., nanowires) thereon and exposing the medical device implant to cells such as osteoblasts.
294 Citations
44 Claims
- 1. A method for enhancing osteoblast functions on a surface of a medical device implant comprising providing a medical device implant comprising a plurality of nanofibers grown thereon and exposing said medical device implant to osteoblast cells.
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5-6. -6. (canceled)
- 10. A method for the repair or regeneration of tissue comprising contacting cells with a nanostructured surface comprising a plurality of nanofibers having an average length of at least about 1 micron and an average density of at least about 1 nanofiber per square micron.
- 33. A method for enhancing osteoblast functions on a surface of a medical device implant comprising providing a medical device implant comprising a plurality of silicon nanofibers and exposing said medical device implant to osteoblast cells.
- 38. A method for enhancing osteoblast adhesion and/or proliferation on a medical device implant surface comprising growing a plurality of nanofibers directly on the surface.
- 43. An orthopedic or dental implant comprising a substrate having a surface and a plurality of silicon nanofibers deposited on the surface.
Specification