High throughput screen
First Claim
1. A structure which comprises a biological membrane adhered with a high resistance seal to a porous or perforated substrate for use in a high throughput screen wherein the biological membrane comprises an ion channel or transporter.
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Accused Products
Abstract
The present invention relates to a structure comprising a biological membrane and a porous or perforated substrate, a biological membrane, a substrate, a high throughput screen, methods for production of the structure membrane and substrate, and a method for screening a large number of test compounds in a short period. More particularly it relates to a structure comprising a biological membrane adhered to a porous or perforated substrate, a biological membrane capable of adhering with high resistance seals to a substrate such as perforated glass and the ability to form sheets having predominantly an ion channel or transporter of interest, a high throughput screen for determining the effect of test compounds on ion channel or transporter activity, methods for manufacture of the structure, membrane and substrate, and a method for monitoring ion channel or transporter activity in a membrane.
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Citations
20 Claims
- 1. A structure which comprises a biological membrane adhered with a high resistance seal to a porous or perforated substrate for use in a high throughput screen wherein the biological membrane comprises an ion channel or transporter.
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20-46. -46. (canceled)
Specification