Method for purifying microbeads
First Claim
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1. A method for purifying a microbead having an immobilized nucleic acid as a target, the method comprising:
- (a) immobilizing a nucleic acid labeled with at least two labeling substances to a microbead through a covalent bond, wherein at least one of the labeling substances is a detectable labeling substance and another labeling substance is a labeling substance capable of binding to a solid phase that is different from the microbead; and
(b) binding the microbead having the immobilized nucleic acid to the solid phase that is different from the microbead to isolate the bound microbead.
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Abstract
A method for purifying a microbead having an immobilized nucleic acid, a kit for the method, a microbead array which is an array of microbeads each having an immobilized nucleic acid, and a kit for preparing the microbead array.
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Citations
10 Claims
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1. A method for purifying a microbead having an immobilized nucleic acid as a target, the method comprising:
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(a) immobilizing a nucleic acid labeled with at least two labeling substances to a microbead through a covalent bond, wherein at least one of the labeling substances is a detectable labeling substance and another labeling substance is a labeling substance capable of binding to a solid phase that is different from the microbead; and
(b) binding the microbead having the immobilized nucleic acid to the solid phase that is different from the microbead to isolate the bound microbead. - View Dependent Claims (2, 3, 4, 5)
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- 6. A microbead array which is an array of microbeads each having an immobilized nucleic acid, wherein the nucleic acid as a target immobilized on each microbead consists of molecules having an identical sequence, the nucleic acid is labeled with at least two labeling substances, at least one of the labeling substances is a detectable labeling substance and another labeling substance is a labeling substance capable of binding to a solid phase that is different from the microbead.
Specification