Polymerase chain reaction using metallic glass-coated microwire
First Claim
1. A metallic glass-coated microwire, wherein said glass has a thermal contraction coefficient less than that of said metallic core by a preselected value, said preselected value being such that said glass is under residual compression, interfacial bonding between said glass and said metallic core is substantially uniform, and surface cracking and bond breaks between metal and glass are substantially prevented.
1 Assignment
0 Petitions
Accused Products
Abstract
A metallic glass-coated microwire has controllable surface porosity. The porosity is achieved by etching the metallic glass-coated microwire or other shapes of glass-coated bodies with acid after annealing to produce a multi-phase glass coating. Porous metallic glass-coated microwires are found to make superior PCR machines, which find use in a variety of in vivo, biochemical, and chemical sensors. Advantageously, the PCR apparatus is smaller, less expensive to construct than conventional units. It readily carries out in vivo passive or active operations.
-
Citations
24 Claims
- 1. A metallic glass-coated microwire, wherein said glass has a thermal contraction coefficient less than that of said metallic core by a preselected value, said preselected value being such that said glass is under residual compression, interfacial bonding between said glass and said metallic core is substantially uniform, and surface cracking and bond breaks between metal and glass are substantially prevented.
-
11. A method for producing a porous metallic glass-coated microwire, comprising the steps of:
-
a. selecting glass that will have multiple phases after heat treatment;
b. heat-treating said glass for time at temperature sufficient to cause formation of multiple phases;
c. immersing said heat-treated, multi-phase glass in selected acid mixture; and
d. continuing step “
c”
until a desired level of glass porosity is achieved.
-
-
12. A process for making porous metallic glass-coated microwire, comprising the steps of:
-
a. selecting glass that will have multiple phases after heat treatment;
b. drawing a glass-coated microwire wherein the coating comprises said selected glass;
c. subjecting said glass-coated microwire to a post-drawing process comprising the steps of;
i. carrying out an acid evaporation/condensation process by placing the metallic glass-coated microwire in a buret containing a select mixture of sulfuric, hydochloric, and nitric acids, followed by evaporation in a flask containing air, so that an acid/air mixture within the flask is heated to create acid vapor;
ii. heat treating said glass-coated microwire;
iii. continuing said heat treatment for at least 20 minutes at a temperature of about 450-700°
C., to allow said acid vapor to flow continuously over said glass for substantially the entire period of said heat treatment until the desired level of glass porosity results; and
iv. cleansing said acid vapor in a condenser before it is liberated.
-
-
21. A detector in which highly polar materials of PCR affect the magnetic output of a metallic glass-coated microwire.
Specification