Synthesis of UDP-glucose: N-acylsphingosine glucosyltransferase inhibitors
First Claim
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1. A compound represented by the following structural formula:
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Abstract
Disclosed is a novel enantiomeric synthesis ceramide-like inhibitors of UDP-glucose: N-acylsphingosine glucosyltransferase. Also disclosed are novel intermediates formed during the synthesis.
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Citations
6 Claims
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1. A compound represented by the following structural formula:
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2. A method of inhibiting glucosylceramide synthase or lowering glycosphingolipid concentrations in a subject in need thereof, comprising administering to the subject an effective amount of a compound represented by the following structural formula:
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3. A method of treating a subject with Tay-Sachs, Gaucher'"'"'s or Fabry'"'"'s disease, comprising administering to the subject an effective amount of a compound represented by the following structural formula:
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4. A compound represented by the following structural formula:
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5. A method of inhibiting glucosylceramide synthase or lowering glycosphingolipid concentrations in a subject in need thereof, comprising administering to the subject an effective amount of a compound represented by the following structural formula:
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6. A method of treating a subject with Tay-Sachs, Gaucher'"'"'s or Fabry'"'"'s disease, comprising administering to the subject an effective amount of a compound represented by the following structural formula:
Specification