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Copper-catalysed ligation of azides and acetylenes

  • US 20050222427A1
  • Filed: 05/30/2003
  • Published: 10/06/2005
  • Est. Priority Date: 05/30/2002
  • Status: Active Grant
First Claim
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1. A process comprising the following step:

  • catalyzing a click chemistry ligation reaction between a first reactant having a terminal alkyne moiety and second reactant having an azide moiety for forming a product having a triazole moiety, the click chemistry ligation reaction being catalyzed by an addition of Cu(II) in the presence of a reducing agent for reducing said Cu(II) to Cu(I), in situ, in catalytic amount.

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