Tachygastrial electrical stimulation
First Claim
1. A method for treatment of obesity in a patient, said method comprising implanting an electrostimulation device comprising at least one electrostimulation lead, a pulse generator, and an electrical connector connecting the at least one electrostimulation lead and the pulse generator, such that the at least one electrostimulation lead is attached to, or adjacent to, the patient'"'"'s stomach, whereby electrical stimulation from the pulse generator can be provided to the stomach through the at least one electrostimulation lead;
- and supplying electrical stimulation to the stomach through the at least one electrostimulation lead;
wherein the electrical stimulation is sufficient to induce tachygastria in the patient and wherein the electrical stimulation has a pulse width of about 50 to about 500 milliseconds.
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Accused Products
Abstract
A process and device for treating obesity and syndromes related to motor disorders of the stomach of a patient is provided. The process includes artificially altering, by means of electrical pulses for preset periods of time, the natural gastric motility of the patient to prevent the emptying of or to slow down gastric transit through the stomach to increase the feeling of satiety and/or to accelerate intestinal transit to reduce absorption time within the intestinal tract. More specifically, the electrical stimulation induces tachygastria, which inhibits gastric motility, yields gastric distention, and delays gastric emptying. The tachygastrial electrical stimulation of the stomach, or other portions of the gastrointestinal tract, includes relatively long pulse widths, with lengths of up to 500 milliseconds.
167 Citations
51 Claims
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1. A method for treatment of obesity in a patient, said method comprising
implanting an electrostimulation device comprising at least one electrostimulation lead, a pulse generator, and an electrical connector connecting the at least one electrostimulation lead and the pulse generator, such that the at least one electrostimulation lead is attached to, or adjacent to, the patient'"'"'s stomach, whereby electrical stimulation from the pulse generator can be provided to the stomach through the at least one electrostimulation lead; - and
supplying electrical stimulation to the stomach through the at least one electrostimulation lead;
wherein the electrical stimulation is sufficient to induce tachygastria in the patient and wherein the electrical stimulation has a pulse width of about 50 to about 500 milliseconds. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 27)
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20. A method for treatment of obesity in a patient, said method comprising
implanting at least two electrostimulation devices, wherein each of the electrostimulation devices comprises at least one electrostimulation lead and an electrical connector for attachment to a pulse generator, such that the at least one electrostimulation lead is attached to, or adjacent to, the patient'"'"'s gastrointestinal tract, whereby electrical stimulation can be provided to the gastrointestinal tract through the at least one electrostimulation lead at two or more different locations along the gastrointestinal tract; - and
supplying electrical stimulation to the gastrointestinal tract through the at least one electrostimulation lead of the two electrostimulation devices at two or more difference locations along the gastrointestinal tract;
wherein the operating frequency of the electrical stimulation is sufficient to induce tachygastria in the patient and wherein the electrical stimulation has a pulse width of about 50 to about 500 milliseconds. - View Dependent Claims (21, 22, 23, 24, 25, 26)
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28. An electrostimulation device for the treatment of obesity in a patient, said electrostimulation device comprising at least one electrostimulation lead, a pulse generator, and an electrical connector connecting the at least one electrostimulation lead and the pulse generator, such that the at least one electrostimulation lead is attached to, or adjacent to, the patient'"'"'s stomach, whereby electrical stimulation from the pulse generator can be provided to the stomach through the at least one electrostimulation lead;
- wherein the electrical stimulation is capable of inducing tachygastria in the patient, wherein the electrical pulse generator includes at least one programmable output variable, wherein the at least one programmable output variable is pulse width, and wherein the electrical stimulation has a pulse width of about 50 to about 500 milliseconds.
- View Dependent Claims (29, 30, 31, 32)
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33. A method for treatment of obesity in a patient, said method comprising
implanting an electrostimulation device comprising at least one electrostimulation lead, a pulse generator, and an electrical connector connecting the at least one electrostimulation lead and the pulse generator, such that the at least one electrostimulation lead is attached to, or adjacent to, the patient'"'"'s stomach, whereby electrical stimulation from the pulse generator can be provided to the stomach through the at least one electrostimulation lead; - and
supplying electrical stimulation to the stomach through the at least one electrostimulation lead;
wherein the electrical stimulation has a pulse width of about 50 to about 500 milliseconds and an operating frequency at least about 30 percent higher than the patient'"'"'s normal gastric slow wave frequency. - View Dependent Claims (34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51)
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Specification