Use of microfabricated devices

• US 20050226776A1
• Filed: 03/14/2003
• Published: 10/13/2005
• Est. Priority Date: 03/15/2002
• Status: Abandoned Application

• Current Assignee: Frank Brady, James Millar Gillies, Nicholas Toby Jeffery, Sajinder Kaur Luthra
• Original Assignee: Frank Brady, James Millar Gillies, Nicholas Toby Jeffery, Sajinder Kaur Luthra
• Inventors: Jeffery, Nicholas Toby, Gillies, James Millar, Luthra, Sajinder Kaur, Brady, Frank
• Application Number:
  US10/507,964
• Publication Number:
  US 20050226776A1
• Time in Patent Office: Days
• US Class Current: 422/99
• CPC Class Codes: B01J 19/0093 Microreactors, e.g. miniaturised or microfabricated reactors laboratory containers with capillary fluid transport in microfabricated channels or chambers B01L3/5027
• CPC Class Codes: B01J 2219/00783 Laminate assemblies, i.e. the reactor comprising a stack of plates
• CPC Class Codes: B01J 2219/00889 Mixing micromixers B01F33/30
• CPC Class Codes: B01J 2219/00905 Separation
• CPC Class Codes: B01J 2219/00952 Sensing operations
• CPC Class Codes: B01L 3/5027 by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip B01L3/5023 takes precedence; micromixers B01F33/30; microreactors for synthesis B01J19/0093; microcapillary devices in general B81B1/00
• CPC Class Codes: B01L 3/502715 characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
• CPC Class Codes: C07B 59/00 Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
• CPC Class Codes: C07B 59/001 Acyclic or carbocyclic compounds
• CPC Class Codes: C07B 59/002 Heterocyclic compounds
• CPC Class Codes: C07B 59/005 Sugars; Derivatives thereof; Nucleosides; Nucleotides; Nucleic acids
• CPC Class Codes: C07C 211/48 N-alkylated amines
• CPC Class Codes: C07C 229/36 with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
• CPC Class Codes: C07D 223/16 Benzazepines; Hydrogenated benzazepines
• CPC Class Codes: C07D 401/04 directly linked by a ring-member-to-ring-member bond
• CPC Class Codes: C07H 5/02 to halogen

Abstract

This invention relates to the miniaturisation of radiosyntheses onto microfabricated devices, and in particular to use of microfabricated devices for radiosynthesis, isolation, and analysis of radiotracers for use in Positron Emission Tomography (PET).

Claims

1. Use of a microfabricated device for radiosynthesis.

5. Use according to claim 1 which comprises one or more of the steps (i) to (vi) performed on a microfabricated device:

(i) pretreatment of a radioactive reagent or a precursor;

(ii) synthesis of a radiolabelling agent;

(iii) mixing and reaction of a radiolabelling agent with a precursor to produce a radiolabelled product;

(iv) chemical modification of a radiolabelled product;

(v) analysis of a radiolabelled product; and

/or

(vi) separation of a radiolabelled product, from one or more byproducts.

6. Use according to claim 5 wherein the radiolabelled product produced is a radiotracer such as 2-[¹⁸F]fluorodeoxyglucose or L-6-[¹⁸F]fluoro-DOPA.

7. Use according to claim 5 wherein the radiolabelling agent is selected from:

[¹¹C]methane;

[¹¹C]carbon dioxide;

[¹¹C]carbon monoxide;

[¹¹C]RX, wherein R is selected from methyl, ethyl, n-propyl, i-propyl, cyclopropyl, benzyl, cyclopentylmethyl, cyclohexylmethyl, and fluoro or halo-analogues thereof; and

X is selected from halo, mesylate, tosylate, triflate, nonaflate, nitrate, thiol, isocyanate, lithium and aldehyde;

R′

[¹¹C]COCl, R′

[¹¹C]COOH, R′

[¹¹C]CH₂OH, R′

[¹¹C]COH, or R′

[¹¹C]COR′

where R′

is selected from methyl, ethyl, n-propyl, i-propyl, cyclopropyl, benzyl, cyclopentylmethyl, cyclohexylmethyl, and fluoro or halo-analogues thereof;

[¹¹C]CN;

[¹¹C]CCl₄;

[¹¹C]phosgene;

[¹¹C]urea;

[¹¹C]cyanogen bromide;

[¹⁸F]fluoride; and

[¹²⁴I]iodide.

8. A microfabricated device adapted to carry out one or more of the steps in claim 5 comprising one or more of:

(i) microfabricated mixing and reaction device;

(ii) microfabricated analysis device; and

/or

(iii) microfabricated separation device.

2. Use of a microfabricated device for radiosynthesis of a radiotracer suitable for use in PET.

3. Use according to claim 2 wherein the radiotracer produced is labelled with ¹¹C, ¹⁸F, or ¹²⁴I.

4. Use according to claim 2 wherein the radiotracer is 2-[¹⁸F]fluorodeoxyglucose or L-6-[¹⁸F]fluoro-DOPA.