Biocompatible compositions as carriers or excipients for pharmaceutical and nutraceutical formulations and for food protection

• US 20050226905A1
• Filed: 05/23/2001
• Published: 10/13/2005
• Est. Priority Date: 05/23/2001
• Status: Abandoned Application

• Current Assignee: Institut national de la recherche scientifique, Université du Québec à Montréal
• Original Assignee: Institut national de la recherche scientifique
• Inventors: Ispas-Szabo, Pompilia, Mateescu, Mircea Alexandru, Tien, Canh Le, Lacroix, Monique
• Application Number:
  US10/478,468
• Publication Number:
  US 20050226905A1
• Time in Patent Office: Days
• US Class Current: 424/439
• CPC Class Codes: A61K 9/0024 Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue compositions for intravenous administration, normal injectable solutions or dispersions for, e.g. subcutaneous administration A61K9/0019; brain implants A61K9/0085; (coated) prostheses, catheters or stents A61L
• CPC Class Codes: A61K 9/1652 Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin homeopathic globules A61K9/1623
• CPC Class Codes: A61K 9/1658 Proteins, e.g. albumin, gelatin
• CPC Class Codes: A61K 9/205 Polysaccharides, e.g. alginate, gums; Cyclodextrin
• CPC Class Codes: A61K 9/2063 Proteins, e.g. gelatin
• CPC Class Codes: A61K 9/7007 Drug-containing films, membranes or sheets A61K9/0041, A61K9/0043, A61K9/006, A61K9/0063 take precedence

Abstract

This invention refers to biocompatible carbohydrate polymers such as modified polysaccharides (e.g. chitosan, alginate), associated with milk protein (e.g. caseinate and/or whey proteins) designed to carry bioactive agents. The formulations may be used in various delivery systems including beads, tablets, microencapsulating agents and coatings for oral dosage forms, implants for subcutaneous devices and films for topic administration and food protection. These formulations present improved chemical resistance and exert their activity for prolonged time into gastrointestinal tract (GIT) and blood circulation as well as for preserving food qualities over long period. The association of modified chitosan, modified alginate with milk proteins results in a stabilized structure able to control the release of drugs, bacteria, bacteriocines, enzymes, nutraceutics, etc. into enteric, topic or systemic route.

Claims

1-30. -30. (canceled)

31. A biocompatible carrier composition comprising a biocompatible carbohydrate polymer, wherein said biocompatible carbohydrate polymer is modified with a hydrophobic group.

32. The composition according to claim 31, wherein the carbohydrate polymer is a polysaccharide.

33. The composition according to claim 32, wherein the polysaccharide is selected from (a) chitosan, (b) alginate and (c) both (a) and (b).

34. The composition according to claim 31, wherein the hydrophobic group is a residue of a fatty acid.

35. The composition according to claim 34, wherein the fatty acid has from three to eighteen carbon atoms.

36. The composition according to claim 35, wherein the fatty acid is selected from palmitic acid, lauric acid, oleic acid, linoleic acid, linolenic acid, caproic acid, caprylic acid, stearic acid, propionic acid and butyric acid.

37. The composition according to claim 31, wherein the carbohydrate polymer is further cross-linked.

38. The composition according to claim 37, wherein the carbohydrate polymer is further cross-linked by a dialdehyde, epichlorohydrin, ethylchloroformate or phosphorus oxychloride.

39. The composition according to claim 38, wherein the dialdehyde is glutaraldehyde.

40. The composition according to claim 31 further comprising a milk protein.

41. The composition according to claim 40, wherein the milk protein is selected from (a) a caseinate, (b) a whey protein and (c) both (a) and (b).

42. The composition according to claim 31 further comprising a bioactive agent.

43. The composition according to claim 42, wherein the bioactive agent is selected from a drug, a vitamin, a mineral, bacteria, a bacteriocine, an anti-oxidant and an anti-microbial.

44. The composition according to claim 43 which is in the form selected from the group consisting of a tablet, an implant, a microsphere and a film.

45. A method of controlling the release of a bioactive agent into an environment comprising:

(a) formulating the bioactive agent in the composition according to claim 31;

and

(b) administering to the environment the composition containing the bioactive agent.

46. A method of formulating a bioactive agent comprising the step of coating, encapsulating or incorporating the bioactive agent with the composition according to claim 31.

47. A method of preparing a pharmaceutical formulation comprising coating, encapsulating or incorporating a bioactive agent with the composition according to claim 31.

48. The method according to claim 47, wherein the pharmaceutical formulation is in the form selected from a tablet, an implant, a microsphere and a film.

49. A method for packaging food comprising the step of coating food with the composition according to claim 31.

50. The method according to claim 49, wherein the coating is in the form of a film.