Delivery system for insulin and other therapeutic agents

• US 20050226918A1
• Filed: 08/12/2002
• Published: 10/13/2005
• Est. Priority Date: 08/13/2001
• Status: Abandoned Application

• Current Assignee: Biomed Solutions, LLC
• Original Assignee: Biomed Solutions, LLC
• Inventors: MacDonald, Stuart G.
• Application Number:
  US10/217,093
• Publication Number:
  US 20050226918A1
• Time in Patent Office: Days
• US Class Current: 424/449
• CPC Class Codes: A61K 9/0009 involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis microelectromechanical systems A61K9/0097
• CPC Class Codes: A61K 9/006 Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
• CPC Class Codes: A61K 9/0097 Micromachined devices; Microelectromechanical systems [MEMS]; Devices obtained by lithographic treatment of silicon; Devices comprising chips intradermal microneedle arrays A61K9/0021; MEMS in general B81B7/02
• CPC Class Codes: A61M 31/002 Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time artificial gland structures or devices A61F2/022; intra-uterine contraceptive devices A61F6/14; tampons for introducing into the vagina A61F13/20, A61L15/00; suppositories or bougies for intra-vaginal or intra-uterine application A61K9/02; physical forms of medicinal preparations for sustained or differential drug release A61K9/20, A61K9/50

Abstract

An automated, non-implanted, closed-loop system for measurement of a biological material in an individual, determination of appropriate steady-state and bolus drug delivery response to the measured level of the biological material, and storage and delivery of a hormone, drug, or other chemical or biochemical therapeutic agent that serves to regulate or otherwise therapeutically react to the biological material.

Claims

1. A delivery system for a therapeutic agent, comprising means for continuously administering said therapeutic agent across a mucosal membrane, said means comprising a delivery pad having at an interface a first capillary chamber in contact with said mucosal membrane.

2. The delivery system as recited in claim 1, further comprising means for delivering said therapeutic agent to said mucosal membrane via a delivery pad comprising-one or more capillary chambers in contact with said mucosal membrane wherein said first capillary chamber composes capillary channels perpendicular to said interface.

3. The delivery system as recited in claim 1, further comprising means for delivering said therapeutic agent to said mucosal membrane via an array of miniature fluid jets.

4. The delivery system as recited in claim 1, further comprising a power source, a reservoir of therapeutic agents, means for recharging said power source, and means for refilling said reservoir of therapeutic agents.

5. The delivery system as recited in claim 1, further comprising means for bidirectional information and command transfer to an external device.

6. The delivery system as recited in claim 1, further comprising means for affixing said system in a mouth of a living organism.

15. The delivery system as recited in claim 2, further comprising a second capillary chamber in contact with said first capillary chamber.

16. The delivery system as recited in claim 15, wherein said second capillary chamber comprises a port disposed therein.

17. The delivery system as recited in claim 16, wherein said second capillary chamber is a radial distribution capillary chamber, said radial distribution occurring from said port outwardly in a direction parallel to said interface.

7. A delivery system for a therapeutic agent, comprising means for monitoring the level of an analyte in a living body, means for computing an appropriate baseline and adjusted continuous administration rate for said therapeutic agent, and means for administering said therapeutic agent across a mucosal membrane.

8. The delivery system as recited in claim 7, further comprising means for delivering said therapeutic agent to said mucosal membrane via a delivery pad comprising one or more capillary chambers in contact with said mucosal membrane.

9. The delivery system as recited in claim 7, further comprising means for delivering said therapeutic agent to said mucosal membrane via an array of miniature fluid jets.

10. The delivery system as recited in claim 7, further comprising a power source, a reservoir of therapeutic agents, means for recharging said power source, and means for refilling said reservoir of therapeutic agents.

11. The delivery system as recited in claim 7, further comprising means for affixing said system in the mouth of a living organism.

12. The delivery system as recited in claim 7, further comprising means for bidirectional information and command transfer to an external device.

13. The delivery system as recited in claim 7, further comprising means for monitoring the level of analyte by using near-infrared optical measurements.

14. The delivery system as recited in claim 7, further comprising means for monitoring the level of analyte by using a chemically treated semiconductor sensor.