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Microarray based affinity purification and analysis device coupled with solid state nanopore electrodes

  • US 20050227239A1
  • Filed: 04/08/2004
  • Published: 10/13/2005
  • Est. Priority Date: 04/08/2004
  • Status: Abandoned Application
First Claim
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1. An apparatus for identifying a chemical moiety from a sample solution, comprising:

  • (a) a substrate having a channel with at least one array for capturing and releasing a chemical moiety from a sample solution; and

    (b) a solid state nanopore system downstream from the substrate for identifying the chemical moiety received from the substrate channel after the chemical moiety has been released from the array, the nanopore system comprising i. a first ring electrode, ii. a second ring adjacent to the first ring electrode;

    iii. a nanopore adjacent to the first ring electrode and the second ring electrode and positioned to allow the chemical moiety to be positioned in the first ring electrode and the second ring electrode; and

    iv. a voltage source for electrically connecting the first ring electrode to the second ring electrode for applying a ramping potential from the first ring electrode, through a portion of the chemical moiety in the nanopore to a second ring electrode to produce a signal indicative of the portion of the chemical moiety.

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