DLC-1 gene deleted in cancers
First Claim
1. A method for diagnosing a cancer in a subject, comprising detecting decreased expression of a nucleic acid encoding SEQ ID NO:
- 2 in a sample from the subject, wherein detection of decreased expression of the nucleic acid encoding SEQ ID NO;
2 diagnoses the cancer.
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Abstract
A cDNA molecule corresponding to a newly discovered human gene is disclosed. The new gene, which is frequently deleted in liver cancer cells and cell lines, is called the DLC-1 gene. Because the gene is frequently deleted in liver cancer cells, but present in normal cells, it is thought to act as a tumor suppressor. This gene is also frequently deleted in breast and colon cancers, and its expression is decreased or undetectable in many prostate and colon cancers. Also disclosed is the amino acid sequence of the protein encoded by the DLC-1 gene. Methods of using these biological materials in the diagnosis and treatment of hepatocellular cancer, breast cancer, colon cancer, prostate cancer, and adenocarcinomas are presented.
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Citations
19 Claims
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1. A method for diagnosing a cancer in a subject, comprising detecting decreased expression of a nucleic acid encoding SEQ ID NO:
- 2 in a sample from the subject, wherein detection of decreased expression of the nucleic acid encoding SEQ ID NO;
2 diagnoses the cancer. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
- 2 in a sample from the subject, wherein detection of decreased expression of the nucleic acid encoding SEQ ID NO;
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12. A method for diagnosing a cancer in a subject, comprising detecting decreased expression of a polypeptide at least 95% identical to SEQ ID NO:
- 2 in a sample from the subject, wherein detection of decreased expression of the polypeptide at least 95% identical to SEQ ID NO;
2 diagnoses the cancer. - View Dependent Claims (13, 14, 15, 16, 17, 18, 19)
- 2 in a sample from the subject, wherein detection of decreased expression of the polypeptide at least 95% identical to SEQ ID NO;
Specification