Method for obtaining medically relevant data from the gastrointestinal tract of a human or an animal and measuring probe suitable therefor

• US 20050228223A1
• Filed: 03/30/2005
• Published: 10/13/2005
• Est. Priority Date: 03/31/2004
• Status: Abandoned Application

• Current Assignee: Siemens AG
• Original Assignee: Siemens AG
• Inventors: Abraham-Fuchs, Klaus, Schmidt, Markus, Rumpel, Eva, Schneider, Siegfried, Schreiner, Horst, Kuth, Rainer, Zahlmann, Gudrun
• Application Number:
  US11/093,279
• Publication Number:
  US 20050228223A1
• Time in Patent Office: Days
• US Class Current: 600/102
• CPC Class Codes: A61B 5/07 Endoradiosondes
• CPC Class Codes: A61B 5/14539 for measuring pH
• CPC Class Codes: A61B 5/42 Detecting, measuring or recording for evaluating the gastrointestinal, the endocrine or the exocrine systems A61B1/00, A61B5/4857, A61B5/486, A61B5/4866, A61B5/4869 take precedence

Abstract

A method is for obtaining medically relevant data from the gastrointestinal tract of a patient (human or an animal). The patient is orally administered with a transponder and signals emitted by the transponder during or after passage through the gastrointestinal tract are received, with the aid of a reading device for example. A measuring probe may be suitable for carrying out the method. The probe is designed as a transponder and includes a sensor unit for recording chemical, electrochemical or physical parameters.

Claims

1. A method for obtaining medically relevant data from a gastrointestinal tract of a patient, comprising:

orally administering, in the patient, a transponder designed to monitor a medication, the transponder being enclosed by a biocompatible protective layer and being integrated in a preparation, the preparation being solid overall or having a solid shell, containing a pharmaceutical active agent, and being dissolvable in the patient'"'"'s gastrointestinal tract; and

receiving signals emitted from the transponder during or after passage through the gastrointestinal tract.

2. The method as claimed in claim 1, wherein at least one of chemical, electrochemical and physical parameters of the gastrointestinal tract are determined with the aid of a sensor unit, integrated in the transponder.

3. The method as claimed in claim 2, wherein the pH of the gastrointestinal tract is determined with the aid of a pH probe integrated in the sensor unit.

4. The method as claimed in claim 3, wherein pathological deviations of pH values prevailing in individual sections of the gastrointestinal tract are detected with the aid of the pH probe.

5. The method as claimed in claim 3, wherein the pH probe is used to establish, for the medication, whether the preparation dissolves in a first section, or in a subsequent section.

6. The method as claimed in claim 2, wherein a biocompatible substrate added to the preparation is detected with the aid of the sensor unit in order to monitor at least one of the dissolving of the preparation and the release of a medicament in the gastrointestinal tract.

7. The method as claimed in claim 1, wherein the transponder is read out by a reading device carried by the patient on their body.

19. The method of claim 5, wherein the first section is the stomach, and the subsequent section is the duodenum.

20. The method as claimed in claim 4, wherein the pH probe is used to establish, for the medication, whether the preparation dissolves in a first section, or in a subsequent section.

21. The method of claim 20, wherein the first section is the stomach, and the subsequent section is the duodenum.

8. A transponder for monitoring the medication of a patient, the transponder being enclosed by a biocompatible protective layer and integrated in a preparation which is solid overall or has a solid shell, the preparation containing a pharmaceutical active agent and being dissolvable in a gastrointestinal tract of the patient after oral administration to the patient, the transponder being adapted to emit signals, receivable by at least one reading device.

9. The transponder as claimed in claim 8, wherein the transponder comprises a sensor unit for recording at least one of chemical, electrochemical and physical parameters.

10. The transponder as claimed in claim 8, wherein the transponder is allocated to the patient using data technology.

11. The transponder as claimed in claim 9, wherein the reading device is arrangeable on a toilet.

12. The transponder as claimed in claim 11, wherein the sensor unit comprises a pH probe.

13. The transponder as claimed in claim 12, wherein the pH probe is adapted to detect pathological deviations of pH values prevailing in individual sections of the gastrointestinal tract.

14. The transponder as claimed in claim 12, wherein the pH probe is adapted to establish for the medication, whether the preparation dissolves in a first section or in a subsequent section.

15. The transponder as claimed in claim 11, wherein the biocompatible protective layer is transparent to radiofrequency electromagnetic radiation.

16. The transponder as claimed in claim 15, further comprising a porous material, in contact with an active sensing region of the sensor unit, across the protective layer.

17. The transponder as claimed in claim 11, further comprising an electronic memory.

18. A pharmaceutical active agent which is integrated in a solid preparation, wherein a transponder as claimed in claim 8 is added to the active agent.

22. The transponder as claimed in claim 13, wherein the pH probe is adapted to establish for the medication, whether the preparation dissolves in a first section or in a subsequent section.

23. The transponder as claimed in claim 14, wherein the first section is the stomach, and the subsequent section is the duodenum.

24. The transponder as claimed in claim 22, wherein the first section is the stomach, and the subsequent section is the duodenum.

25. A transponder for monitoring the medication of a patient, the transponder being enclosed by a biocompatible protective layer and integrated in a preparation which at least includes a solid shell, the preparation containing a pharmaceutical active agent and being dissolvable in a gastrointestinal tract of the patient after oral administration to the patient, the transponder including a sensor unit for recording at least one of chemical, electrochemical and physical parameters.

26. The transponder as claimed in claim 25, wherein the transponder is adapted to emit signals, receivable by at least one reading device.