Microfluidic apparatus and method for synthesis of molecular imaging probes
First Claim
1. A method for synthesizing a radiochemical in a microfluidic environment, the method comprising:
- i) providing a micro reactor comprising a first inlet port, a second inlet port, an outlet port, and at least one microchannel in fluid communication with the first and second inlet ports and the outlet port;
ii) introducing a reactive precursor into the first inlet port of the micro reactor, the reactive precursor adapted for reaction with a radioactive isotope to form a radiochemical;
iii) introducing a solution comprising a radioactive isotope into the second inlet port of the micro reactor;
iv) contacting the reactive precursor with the isotope-containing solution in the microchannel of the micro reactor;
v) reacting the reactive precursor with the isotope-containing solution as the reactive precursor and isotope-containing solution flow through the microchannel of the micro reactor, said reacting step resulting in formation of a radiochemical; and
vi) collecting the radiochemical from the outlet port of the micro reactor.
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Abstract
The invention provides a method and apparatus for preparation of radiochemicals, such as PET molecular imaging probes, wherein the reaction step or steps that couple the radioactive isotope to an organic or inorganic compound to form a positron-emitting molecular imaging probe are performed in a microfluidic environment. The method for synthesizing a radiochemical in a microfluidic environment comprises: i) providing a micro reactor comprising a first inlet port, a second inlet port, an outlet port, and at least one microchannel in fluid communication with the first and second inlet ports and the outlet port; ii) introducing a reactive precursor into the first inlet port of the micro reactor, the reactive precursor adapted for reaction with a radioactive isotope to form a radiochemical; iii) introducing a solution comprising a radioactive isotope into the second inlet port of the micro reactor; iv) contacting the reactive precursor with the isotope-containing solution in the microchannel of the micro reactor; v) reacting the reactive precursor with the isotope-containing solution as the reactive precursor and isotope-containing solution flow through the microchannel of the micro reactor, the reacting step resulting in formation of a radiochemical; and vi) collecting the radiochemical from the outlet port of the micro reactor.
61 Citations
42 Claims
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1. A method for synthesizing a radiochemical in a microfluidic environment, the method comprising:
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i) providing a micro reactor comprising a first inlet port, a second inlet port, an outlet port, and at least one microchannel in fluid communication with the first and second inlet ports and the outlet port;
ii) introducing a reactive precursor into the first inlet port of the micro reactor, the reactive precursor adapted for reaction with a radioactive isotope to form a radiochemical;
iii) introducing a solution comprising a radioactive isotope into the second inlet port of the micro reactor;
iv) contacting the reactive precursor with the isotope-containing solution in the microchannel of the micro reactor;
v) reacting the reactive precursor with the isotope-containing solution as the reactive precursor and isotope-containing solution flow through the microchannel of the micro reactor, said reacting step resulting in formation of a radiochemical; and
vi) collecting the radiochemical from the outlet port of the micro reactor. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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15. A method for synthesizing a fluorine-18 fluoride labeled radiochemical in a microfluidic environment, the method comprising:
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i) providing a micro reactor comprising a first inlet port, a second inlet port, an outlet port, and at least one microchannel in fluid communication with the first and second inlet ports and the outlet port;
ii) introducing a liquid organic reactive precursor dissolved in a polar aprotic solvent into the first inlet port of the micro reactor, the organic reactive precursor adapted for reaction with fluorine-18 fluoride to form a radiochemical;
iii) introducing a solution comprising fluorine-18 fluoride dissolved in a polar aprotic solvent into the second inlet port of the micro reactor;
iv) contacting the organic reactive precursor with the isotope-containing solution in the microchannel of the micro reactor;
v) reacting the organic reactive precursor with the fluorine-18 fluoride solution in a nucleophilic substitution reaction as the reactive precursor and fluorine-18 fluoride solution flow through the microchannel of the micro reactor, said reacting step resulting in formation of a fluorine-18 fluoride labeled radiochemical; and
vi) collecting the fluorine-18 fluoride labeled radiochemical from the outlet port of the micro reactor. - View Dependent Claims (16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27)
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28. A system for synthesizing a radiochemical in a microfluidic environment, the system comprising:
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a micro reactor comprising a first inlet port, a second inlet port, an outlet port, and at least one microchannel in fluid communication with the first and second inlet ports and the outlet port;
a supply of a reactive precursor in fluid communication with the first inlet port of the micro reactor, the reactive precursor adapted for reaction with a radioactive isotope to form a radiochemical; and
a supply of a solution comprising a radioactive isotope in fluid communication with the second inlet port of the micro reactor. - View Dependent Claims (29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42)
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Specification