Local administration of a combination of rapamycin and 17 beta-estradiol for the treatment of vulnerable plaque
First Claim
1. A medical device for the treatment of atherosclerotic vulnerable plaque comprising:
- a stent for maintaining vessel patentcy and providing structural support for a fibrous cap of the vulnerable plaque lesion;
a biocompatible vehicle affixed to at least a portion of the stent; and
a combination of a rapamycin and 17 beta-estradiol, in therapeutic dosages, incorporated into the biocompatible vehicle for treating at least one of the fibrous cap and a lipid core of the vulnerable plaque lesion.
2 Assignments
0 Petitions
Accused Products
Abstract
Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism'"'"'s reaction to the introduction of the medical device to the organism. The medical devices may be coated with any number of biocompatible materials. Therapeutic drugs, agents or compounds may be mixed with the biocompatible materials and affixed to at least a portion of the medical device. These therapeutic drugs, agents or compounds may also further reduce a biological organism'"'"'s reaction to the introduction of the medical device to the organism. In addition, these therapeutic drugs, agents and/or compounds may be utilized to promote healing, including the formation of blood clots. The drugs, agents, and/or compounds may also be utilized to treat specific diseases, including vulnerable plaque. Therapeutic agents may also be delivered to the region of a disease site. In regional delivery, liquid formulations may be desirable to increase the efficacy and deliverability of the particular drug. Also, the devices may be modified to promote endothelialization. Various materials and coating methodologies may be utilized to maintain the drugs, agents or compounds on the medical device until delivered and positioned. In addition, the devices utilized to deliver the implantable medical devices may be modified to reduce the potential for damaging the implantable medical device during deployment. Medical devices include stents, grafts, anastomotic devices, perivascular wraps, sutures and staples. In addition, various polymer combinations may be utilized to control the elution rates of the therapeutic drugs, agents and/or compounds from the implantable medical devices.
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Citations
5 Claims
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1. A medical device for the treatment of atherosclerotic vulnerable plaque comprising:
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a stent for maintaining vessel patentcy and providing structural support for a fibrous cap of the vulnerable plaque lesion;
a biocompatible vehicle affixed to at least a portion of the stent; and
a combination of a rapamycin and 17 beta-estradiol, in therapeutic dosages, incorporated into the biocompatible vehicle for treating at least one of the fibrous cap and a lipid core of the vulnerable plaque lesion. - View Dependent Claims (2, 3, 4, 5)
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Specification