Process and systems for biocompatible surfaces
First Claim
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1. A medical article having a bioactive agent-releasing coating having heparin activity of 10 mU/cm2 or greater, the coating comprising:
- (a) a first coated layer comprising bio-stable or biodegradable polymer and bioactive agent; and
(b) a second coated layer comprising heparin and photoreactive groups.
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Abstract
The invention provides methods and compositions for providing biocompatible surfaces to medical articles. In particular the invention provides biocompatible coatings with heparin activity that are able to release a bioactive agent, wherein the coatings are formed using biostable or biodegradable polymeric material and photoreactive groups.
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Citations
24 Claims
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1. A medical article having a bioactive agent-releasing coating having heparin activity of 10 mU/cm2 or greater, the coating comprising:
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(a) a first coated layer comprising bio-stable or biodegradable polymer and bioactive agent; and
(b) a second coated layer comprising heparin and photoreactive groups. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. A method for forming a medical article having a biodegradable coating with heparin activity, the method comprising steps of:
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(a) providing a medical article having a first coated layer comprising bio-stable or biodegradable polymer and bioactive agent, wherein the bioactive agent maximally absorbs light at a wavelength of below 300 nm; and
(b) forming a second coated layer comprising heparin and photoreactive groups that maximally absorb light at a wavelength of 320 nm or above, wherein forming comprises applying irradiation through a filter in an amount in the range of 0.12 J/cm2 to 0.96 J/cm2 as measured at 335 nm, wherein the filter is selected from the group consisting of from ultra-violet cut-off filters, ultra-violet transmitting filters, band pass filters, and colored filters. - View Dependent Claims (15, 16, 17, 18, 19, 20, 21)
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22. A medical article having a coating with heparin activity, the coating comprising:
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(a) a first coated layer comprising polymer and bioactive agent, wherein the bioactive agent maximally absorbs light at a wavelength of below 300 nm; and
(b) a second coated layer comprising heparin and photoreactive groups, wherein the photoreactive groups maximally absorb light at a wavelength of 320 nm or above, wherein the second coated layer is formed by applying irradiation through a filter in an amount in the range of 0.12 J/cm2 to 0.96 J/cm2 as measured at 335 nm, and wherein the filter is selected from the group consisting of from ultra-violet cut-off filters, ultra-violet transmitting filters, band pass filters, and colored filters.
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23. A medical article having a coating with heparin activity, the coating comprising:
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(a) a first coated layer comprising a polymer selected from vinyl polymers, and a bioactive agent; and
(b) a second coated layer comprising heparin and photoreactive groups.
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24. A medical article having a biodegradable coating with heparin activity, the coating comprising:
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(a) biodegradable polymer;
(b) bioactive agent;
(c) heparin having pendent photo-reactive groups; and
(d) a component selected from the group of non-water soluble crosslinking agents, vinylpyrrolidone polymers, polyethylene glycol, polyethylene glycol sulfonates, fatty quaternary amines, fatty sulfonates, fatty acids, dextran, dextrin, and cyclodextrin, the component having pendent photo-reactive groups.
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Specification