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Polypeptide variants with altered effector function

  • US 20050233382A1
  • Filed: 06/22/2005
  • Published: 10/20/2005
  • Est. Priority Date: 01/15/1999
  • Status: Active Grant
First Claim
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1. A polypeptide comprising a variant human IgG1 Fc region which displays reduced binding to an Fcγ

  • R, which polypeptide comprises an amino acid substitution at any one or more of amino acid positions 238, 265, 269, 270, 327 or 329 of the Fc region, wherein the numbering of the residues in the Fc region is that of the EU index as in Kabat.

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