Compositions and methods of use of W-peptides
First Claim
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1. A method of modulating an immune response in a subject comprising:
- administering to the subject an amount sufficient to modulate an immune response in the subject of at least one W-peptide or a conservative variant or a functional fragment thereof and at least one antigen.
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Abstract
The present invention relates to compositions and methods to modulating immune responses, such as those elicited by vaccination with W peptides. The compositions and methods are useful for, among other things, vaccine formulation for therapeutic and prophylactic vaccination (immunization) and for production of useful antibodies (e.g., monoclonal antibodies, for therapeutic or diagnostic use).
16 Citations
54 Claims
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1. A method of modulating an immune response in a subject comprising:
administering to the subject an amount sufficient to modulate an immune response in the subject of at least one W-peptide or a conservative variant or a functional fragment thereof and at least one antigen. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29)
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30. A method of producing antibodies to an antigen in a subject comprising:
administering to the subject at least one antigen and at least one W-peptide or a conservative variant or a functional fragment thereof, in an amount sufficient to elicit production of antibodies to the antigen in the subject. - View Dependent Claims (31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46)
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47. A composition comprising:
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at least one W-peptide or conservative variant or a functional fragment thereof;
at least one antigen; and
a pharmaceutically acceptable carrier. - View Dependent Claims (48, 49, 50, 51, 52, 53, 54)
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Specification